"Acetylcholinesterase; Reactivator; PNPA; Reactivation; Verve agents; Inhibition"@en . "22310" . . . "233-237" . "Byly sytetizov\u00E1ny nov\u00E9 typy kvartern\u00EDch pyridiniov\u00FDch ketoxim\u016F, jejich\u017E \u00FA\u010Dinnost byla testov\u00E1na na modelov\u00FDch substr\u00E1tech."@cs . "1475-6366" . . "A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents"@en . . . "A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents" . . "6"^^ . "Nov\u00E9 monokvartern\u00ED reaktiv\u00E1tory acetylcholinester\u00E1zy inhibovan\u00E9 nervov\u00FDmi jedy"@cs . . "Nov\u00E9 monokvartern\u00ED reaktiv\u00E1tory acetylcholinester\u00E1zy inhibovan\u00E9 nervov\u00FDmi jedy"@cs . "Cabal, J." . . . "5"^^ . . . "510946" . . "A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents" . "Journal of Enzyme Inhibition and Medicinal Chemistry" . "Li\u0161ka, Franti\u0161ek" . "Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are able to treat intoxication by organophosphorus compounds,especially with pesticides or nerve agents. Owing to the fact that there exists no universal #broad-spectrum# reactivator oforganophosphates-inhibited AChE, many laboratories have synthesized new AChE reactivators. Here, we synthesized fivenew and three previously known quaternary monopyridinium oximes as potential reactivators of AChE inhibited by nerveagents. Potencies to cleave p-nitrophenyl acetate (PNPA), which is commonly used as a model substrate of nerve agents, were measured. Their cleaving potencies were compared with 4-PAM (4-hydroxyiminomethyl-1-methylpyridinium iodide), which is derived from the structure of the currently used AChE-reactivator 2-PAM (2-hydroxyiminomethyl-1-methylpyridiniumiodide). Three newly synthesized oximes achieved similar nucleophilicity at the similar pKa according to 4-PAM, which is very promising for using these derivatives as AChE reactivators."@en . "A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents"@en . . . "2"^^ . "RIV/60461373:22310/05:00013840!RIV06-MSM-22310___" . "RIV/60461373:22310/05:00013840" . "P(GA203/01/1093), Z(MSM 223100001)" . "Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are able to treat intoxication by organophosphorus compounds,especially with pesticides or nerve agents. Owing to the fact that there exists no universal #broad-spectrum# reactivator oforganophosphates-inhibited AChE, many laboratories have synthesized new AChE reactivators. Here, we synthesized fivenew and three previously known quaternary monopyridinium oximes as potential reactivators of AChE inhibited by nerveagents. Potencies to cleave p-nitrophenyl acetate (PNPA), which is commonly used as a model substrate of nerve agents, were measured. Their cleaving potencies were compared with 4-PAM (4-hydroxyiminomethyl-1-methylpyridinium iodide), which is derived from the structure of the currently used AChE-reactivator 2-PAM (2-hydroxyiminomethyl-1-methylpyridiniumiodide). Three newly synthesized oximes achieved similar nucleophilicity at the similar pKa according to 4-PAM, which is very promising for using these derivatives as AChE reactivators." . "[8F2FF97D19DE]" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "Kohout, Michal" . . "P\u00EDcha, Jan" . "20" . . "Kivala, Milan" . . . . . "3" . "Ku\u010Da, K." .