"Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents" . . . "Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents"@en . . "Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents" . "Synt\u00E9za t\u0159\u00ED monopyridiniov\u00FDch oxim\u016F a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervov\u00FDmi jedy"@cs . . "Synt\u00E9za t\u0159\u00ED monopyridiniov\u00FDch oxim\u016F a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervov\u00FDmi jedy"@cs . . . . "6"^^ . "Cabal, Ji\u0159\u00ED" . "There were synthesized three potential reactivators of nerve agents-inhibited acetylcholinesterase: 2-[(hydroxyimino)phenylmethyl]-1-methylpyridinium iodide 3a, 2-[(hydroxyimino)pyridin-2-ylmethyl]-1-methylpyridinium iodide 3b and 2-[(1-hydroxyimino) ethyl]-1-methylpyridinium iodide 3c. Their reactivation potency was examined using standard in vitro reactivation test. As the source of acetylcholinesterase was used rat brain homogenate. Their reactivation potency was compared with currently used acetylcholinesterase reactivator - 2-PAM (pralidoxime) 4. All tested reactivator were worse acetylcholinesterase reactivators in regard to 2-PAM. In this paper we have also tested reactivation potency of the oxime 2-PAM against inhibition acetylcholinesterase by sarin, cyclosarin, VX and tabun. Satisfactory results are shown only by reactivation sarin- and VX-inhibited acetylcholinesterase." . "VX; reactivation; acetylcholinesterase; oximes; sarin; tabun; cyclosarin"@en . "22310" . . "CZ - \u010Cesk\u00E1 republika" . . . "Journal of Applied Biomedicine" . "Ku\u010Da, Kamil." . "2"^^ . . "10" . . "Synt\u00E9za t\u0159\u00ED monopyridiniov\u00FDch oxim\u016F a studium jejich schopnosti reaktivovat acetylcholinesterasu inhibovanou nervov\u00FDmi jedy"@cs . "2" . "RIV/60461373:22310/04:00020154" . . "Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents"@en . "4"^^ . . . "There were synthesized three potential reactivators of nerve agents-inhibited acetylcholinesterase: 2-[(hydroxyimino)phenylmethyl]-1-methylpyridinium iodide 3a, 2-[(hydroxyimino)pyridin-2-ylmethyl]-1-methylpyridinium iodide 3b and 2-[(1-hydroxyimino) ethyl]-1-methylpyridinium iodide 3c. Their reactivation potency was examined using standard in vitro reactivation test. As the source of acetylcholinesterase was used rat brain homogenate. Their reactivation potency was compared with currently used acetylcholinesterase reactivator - 2-PAM (pralidoxime) 4. All tested reactivator were worse acetylcholinesterase reactivators in regard to 2-PAM. In this paper we have also tested reactivation potency of the oxime 2-PAM against inhibition acetylcholinesterase by sarin, cyclosarin, VX and tabun. Satisfactory results are shown only by reactivation sarin- and VX-inhibited acetylcholinesterase."@en . "P\u00EDcha, Jan" . "1214-021X" . . . . "P(GA203/01/1093), P(ONVLAJEP20031)" . . . "[DA1CCC33EB84]" . "589370" . "Li\u0161ka, Franti\u0161ek" . "RIV/60461373:22310/04:00020154!RIV09-GA0-22310___" . .