. . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "1"^^ . "Stereochemistry od styrene biotransformation"@en . . . . "Stereochemistry od styrene biotransformation" . "RIV/60461373:22310/01:00004353!RIV/2004/MSM/223104/N" . "16"^^ . "0360-2532" . . "353-368" . "Metabolism of styrene, an important industrial monomer, is reviewed. The attention is focused on the stereoselectivity of its oxidation to 7,8-styrene oxide as well as on further stereoselective biotransformation by hydrolytic and mercapturic acid pathway. Toxic effects such as mutagenicity, genotoxicity, hepatotoxicity, and pneumotoxicity may be related to the ratio of styrene oxide enantiomers at the target site. In rats formation of the less mutagenic (S)-styrene oxide and a faster detoxication of the (R)-enantiomer is favored. In mice metabolic activation of styrene favors the formation of (R)-styrene oxide but this more toxic enantiomer is detoxified faster, so that a nearly racemic styrene oxide results. Stereochemistry" . "33" . . . "Z(MSM 223100001)" . . . . "Drug Metabolism Reviews" . "22310" . . "[D8A01AF97C6B]" . "Stereochemistry od styrene biotransformation"@en . "Metabolism of styrene, an important industrial monomer, is reviewed. The attention is focused on the stereoselectivity of its oxidation to 7,8-styrene oxide as well as on further stereoselective biotransformation by hydrolytic and mercapturic acid pathway. Toxic effects such as mutagenicity, genotoxicity, hepatotoxicity, and pneumotoxicity may be related to the ratio of styrene oxide enantiomers at the target site. In rats formation of the less mutagenic (S)-styrene oxide and a faster detoxication of the (R)-enantiomer is favored. In mice metabolic activation of styrene favors the formation of (R)-styrene oxide but this more toxic enantiomer is detoxified faster, so that a nearly racemic styrene oxide results. Stereochemistry"@en . "697240" . "3-4" . . "Linhart, Igor" . "Stereochemistry od styrene biotransformation" . "styren; enantiomery styren-7,8-oxideu; stereoselektivita biotransformace; merkapturov\u00E9 kyseliny; toxicita."@en . "0"^^ . "1"^^ . "0"^^ . . . "RIV/60461373:22310/01:00004353" . . . .