"AQUATIC TOXICOLOGY" . "Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo"@en . "Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo" . "Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo"@en . "0166-445X" . "Golshan, Mahdi" . . . "1"^^ . "P(EE2.3.20.0024), P(GAP503/12/1834), P(GP13-34049P), S" . . . "The fungicide vinclozolin (VZ) is in use globally and known to disrupt reproductive function in male. The present study tested the hypothesis that VZ disrupts testicular function in goldfish (Carassius auratus) by affecting brain-pituitary-testis axis. Goldfish were exposed to 100, 400 and 800 \u00B5g/L VZ and 5 \u00B5g/L 17\u00DF-estradiol (E2) for comparison. In VZ treated goldfish, 11-ketotesteosterone (11-KT) secretion was changed depending on dose and duration period of treatment. Following 7 days of exposure, 11-KT was decreased in goldfish exposed to 800 \u00B5g/L VZ, while it was increased in goldfish exposed to 100 \u00B5g/L VZ after 30 days of exposure. Circulating E2 level was unchanged in VZ treated goldfish, however the E2/11-KT ratio was increased in a dose-related manner. In E2 treated goldfish, circulatory 11-KT and E2 levels were decreased and increased respectively, which resulted in an increase in the E2/11-KT ratio. Exposure to VZ at 100 \u00B5g/L caused a significant increase in the circulatory luteinizing ho" . "N" . "Hatef, Azadeh" . "41210" . "000342245300009" . . "Gosiewski, Grzegorz" . . . "[5B48C9883403]" . "2249" . "11"^^ . . "The fungicide vinclozolin (VZ) is in use globally and known to disrupt reproductive function in male. The present study tested the hypothesis that VZ disrupts testicular function in goldfish (Carassius auratus) by affecting brain-pituitary-testis axis. Goldfish were exposed to 100, 400 and 800 \u00B5g/L VZ and 5 \u00B5g/L 17\u00DF-estradiol (E2) for comparison. In VZ treated goldfish, 11-ketotesteosterone (11-KT) secretion was changed depending on dose and duration period of treatment. Following 7 days of exposure, 11-KT was decreased in goldfish exposed to 800 \u00B5g/L VZ, while it was increased in goldfish exposed to 100 \u00B5g/L VZ after 30 days of exposure. Circulating E2 level was unchanged in VZ treated goldfish, however the E2/11-KT ratio was increased in a dose-related manner. In E2 treated goldfish, circulatory 11-KT and E2 levels were decreased and increased respectively, which resulted in an increase in the E2/11-KT ratio. Exposure to VZ at 100 \u00B5g/L caused a significant increase in the circulatory luteinizing ho"@en . . . "155" . "Soko\u0142owska-Miko\u0142ajczyk, Miros\u0142awa" . "RIV/60460709:41210/14:64302" . . "Habibi, Hamid R." . . "Alavi, Sayyed Mohammad Hadi" . . "Socha, Magdalena" . . "Fontaine, Pascal" . "Milla, Sylvain" . "CZ - \u010Cesk\u00E1 republika" . . . . . "Zare, Ava" . "10"^^ . . "Cytochrome P450 aromatase, Luteinizing hormone, Gonadotropin-releasing hormone, Sex steroids, Sex steroid receptors, Steroidogenic enzyme genes"@en . . . "RIV/60460709:41210/14:64302!RIV15-MSM-41210___" . "Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo" .