"80210" . "Dvo\u0159\u00E1kov\u00E1, Marcela" . "Quinones are compounds frequently contained in medicinal plants used for the treatment of inflammatory diseases. Therefore, the impact of plant-derived quinones on the arachidonic acid metabolic pathway is worthy of investigation. In this study, twenty-three quinone compounds of plant origin were tested in vitro for their potential to inhibit leukotriene B-4 (LTB4) biosynthesis in activated human neutrophil granulocytes with 5-lipoxygenase (5-LOX) activity. The benzoquinones primin (3) and thymohydroquinone (4) (IC50 = 4.0 and 4.1 mu M, respectively) showed activity comparable with the reference inhibitor zileuton (IC50 = 4.1 mu M). Moderate activity was observed for the benzoquinone thymoquinone (2) (IC50 = 18.2 mu M) and the naphthoquinone shikonin (1) (IC50 = 24.3 mu M). The anthraquinone emodin and the naphthoquinone plumbagin (5) displayed only weak activities (IC50 > 50 mu M). The binding modes of the active compounds were further evaluated in silico by molecular docking to the human 5-LOX crys" . "Van\u011Bk, Tom\u00E1\u0161" . "41210" . "P\u0159ibylov\u00E1, Marie" . . "Mal\u00EDk, Jan" . . "8" . "000314617200027" . . "I, P(GP525/09/P528), P(MEB061112), S, Z(AV0Z50380511)" . "Temml, Veronika" . "Bauer, Rudolf" . . "Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones" . . . . . "1934-578X" . . "5-Lipoxygenase, Anti-inflammatory activity, Dual COX/LOX inhibition, Natural compounds, Molecular docking"@en . . "Koko\u0161ka, Ladislav" . "[F39A27872A41]" . "Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones"@en . . "Kutil, Zs\u00F3fia" . . . . . . "4"^^ . "Widowitz, Ute" . "Landa, P\u0159emysl" . . "Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones" . . "Quinones are compounds frequently contained in medicinal plants used for the treatment of inflammatory diseases. Therefore, the impact of plant-derived quinones on the arachidonic acid metabolic pathway is worthy of investigation. In this study, twenty-three quinone compounds of plant origin were tested in vitro for their potential to inhibit leukotriene B-4 (LTB4) biosynthesis in activated human neutrophil granulocytes with 5-lipoxygenase (5-LOX) activity. The benzoquinones primin (3) and thymohydroquinone (4) (IC50 = 4.0 and 4.1 mu M, respectively) showed activity comparable with the reference inhibitor zileuton (IC50 = 4.1 mu M). Moderate activity was observed for the benzoquinone thymoquinone (2) (IC50 = 18.2 mu M) and the naphthoquinone shikonin (1) (IC50 = 24.3 mu M). The anthraquinone emodin and the naphthoquinone plumbagin (5) displayed only weak activities (IC50 > 50 mu M). The binding modes of the active compounds were further evaluated in silico by molecular docking to the human 5-LOX crys"@en . "1"^^ . . "Natural Product Communications" . "RIV/60460709:41210/13:60053!RIV14-MSM-41210___" . "Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones"@en . . "CZ - \u010Cesk\u00E1 republika" . "RIV/60460709:41210/13:60053" . "1" . "Schuster, Daniela" . . . "12"^^ . . "Mar\u0161\u00EDk, Petr" .