"RIV/60460709:41210/06:16336" . . "51" . "RIV/60460709:41210/06:16336!RIV07-MSM-41210___" . "Z(MSM6046070901)" . . . "Sedm\u00EDkov\u00E1, Mark\u00E9ta" . "Koli\u00EDm, \u0161elti\u00EDm, australsk\u00FDm ov\u010D\u00E1k\u016Fm, bobtail\u016Fm, vipet\u016Fm \u010Di border koli\u00EDm m\u016F\u017Ee u\u0161kodit pod\u00E1n\u00ED n\u011Bkter\u00FDch l\u00E9k\u016F. P\u0159\u00ED\u010Dinou citlivosti n\u011Bkter\u00FDch ps\u016F je naru\u0161en\u00ED funkce MDR1 genu. MDR1 k\u00F3duje vznik b\u00EDlkoviny P-glykoproteinu, je\u017E je zodpov\u011Bdn\u00E1 za odstra\u0148ov\u00E1n\u00ED n\u011Bkter\u00FDch l\u00E9k\u016F a toxick\u00FDch l\u00E1tek zmozku. Pes posti\u017Een\u00FD MDR1 je recesivn\u00EDm homozygotem. Po pod\u00E1n\u00ED l\u00E9ku vykazuje neurotoxick\u00E9 p\u0159\u00EDznaky. Vsou\u010Dasn\u00E9 dob\u011B je dostupn\u00FD genetick\u00FD test, je\u017E je schopen mutaci genu MDR odhalit. Obrovskou v\u00FDhodou je, \u017Ee test dok\u00E1\u017Ee odhalit rovn\u011B\u017E skryt\u00E9 p\u0159ena\u0161e\u010De tohoto onemocn\u011Bn\u00ED."@cs . . . . "Chmel\u00EDkov\u00E1, Eva" . "Co je MDR1? Farmakogenomika a molekul\u00E1rn\u00ED biologie v chovu ps\u016F" . "CZ - \u010Cesk\u00E1 republika" . . "Koli\u00EDm, \u0161elti\u00EDm, australsk\u00FDm ov\u010D\u00E1k\u016Fm, bobtail\u016Fm, vipet\u016Fm \u010Di border koli\u00EDm m\u016F\u017Ee u\u0161kodit pod\u00E1n\u00ED n\u011Bkter\u00FDch l\u00E9k\u016F. P\u0159\u00ED\u010Dinou citlivosti n\u011Bkter\u00FDch ps\u016F je naru\u0161en\u00ED funkce MDR1 genu. MDR1 k\u00F3duje vznik b\u00EDlkoviny P-glykoproteinu, je\u017E je zodpov\u011Bdn\u00E1 za odstra\u0148ov\u00E1n\u00ED n\u011Bkter\u00FDch l\u00E9k\u016F a toxick\u00FDch l\u00E1tek zmozku. Pes posti\u017Een\u00FD MDR1 je recesivn\u00EDm homozygotem. Po pod\u00E1n\u00ED l\u00E9ku vykazuje neurotoxick\u00E9 p\u0159\u00EDznaky. Vsou\u010Dasn\u00E9 dob\u011B je dostupn\u00FD genetick\u00FD test, je\u017E je schopen mutaci genu MDR odhalit. Obrovskou v\u00FDhodou je, \u017Ee test dok\u00E1\u017Ee odhalit rovn\u011B\u017E skryt\u00E9 p\u0159ena\u0161e\u010De tohoto onemocn\u011Bn\u00ED." . . . "Pes p\u0159\u00EDtel \u010Dlov\u011Bka" . "L\u00E1nsk\u00E1, Vilma" . . "dog, molecular biology, farmacogenomics, MDR1"@en . . "Co je MDR1? Farmakogenomika a molekul\u00E1rn\u00ED biologie v chovu ps\u016F"@cs . . "H\u00E4rtlov\u00E1, Helena" . "5"^^ . "What MDR1 is? Farmacogenomics and molecular biology in dog breeding"@en . . . . "10;12" . "5"^^ . . . "Co je MDR1? Farmakogenomika a molekul\u00E1rn\u00ED biologie v chovu ps\u016F" . . "468939" . "Application of certain drugs could be dangerous for some dog breed collie, sheltie, Australian shepherds, bobtails, vipets or border collies. The reason of sensitivity is mutation of MDR1 gene. MDR1 gene encodes formation of P-glycoprotein, which plays a role in removing of some drugs and toxic substance from brain. The dog, which is affected by MDR1, is recessive homozygote. After drug application he embodies signs of neurotoxicity. Just now, genetic test for MDR gene mutation is available. A big advantage of this genetic test is, that this test can detect hidden carriers of MDR disease."@en . . "[216DB86E1859]" . "Co je MDR1? Farmakogenomika a molekul\u00E1rn\u00ED biologie v chovu ps\u016F"@cs . "What MDR1 is? Farmacogenomics and molecular biology in dog breeding"@en . . "12" . "3"^^ . "Petr, Jaroslav" . "41210" . "0231-5424" .