"[10DD8CE83950]" . "Hol\u010Dapek, Michal" . . "2008-09-26+02:00"^^ . "Ve\u010De\u0159a, Rostislav" . "Neapol" . "\u0160varcov\u00E1, Irena" . . . . "P(FT-TA2/014)" . "Ulrychov\u00E1, Jitka" . "A 90-day safety study of isomerized hop extract in rats"@en . . "RIV/60318287:_____/08:#0000015" . . . . . "126"^^ . "Pilotn\u00ED 90ti denn\u00ED studie izomerizovan\u00E9ho chmelov\u00E9ho extraktu na potkanech"@cs . "Ehrman, Ji\u0159\u00ED" . . . . . . "The objective of this study was to evaluate the safety of the isomerized hop extract (IHE) obtained from hop cones waste, in comparison with CO2 hop extract, in rodents. The rats consumed ad libitum either the standard diet (control Group 1) or diets with IHE containing 100 mg XN + IXN/kg feed (Group 2) or 1000 mg XN + IXN/kg feed (Group 3), and 1000 mg CO2 hop extract/kg feed (Group 4) for 90 days. After 90 days the rats were sacrificed and organ and blood samples were collected. CONCLUSIONS: Isomerized hop and CO2 hop extracts did not affect major organ functions. However, both affected the antioxidant status of rats. We found lowered level of GSH in Group 3 or 4, decreased GPx activity in Groups 2, 3 and 4, and significantly increased ALT activity in Group 4. Body weight of animals in Group 3 and 4 was insignificantly decreased in comparison to control rats."@en . "117"^^ . . "Pilotn\u00ED 90ti denn\u00ED studie izomerizovan\u00E9ho chmelov\u00E9ho extraktu na potkanech" . "A 90-day safety study of isomerized hop extract in rats"@en . "8"^^ . . "\u0160im\u00E1nek, Vil\u00EDm" . . . "Pilotn\u00ED 90ti denn\u00ED studie izomerizovan\u00E9ho chmelov\u00E9ho extraktu na potkanech"@cs . "hop; Humulus lupulus L.; xanthohumol; isomerized extract"@en . . "Vrublov\u00E1, Eva" . "386684" . "Vost\u00E1lov\u00E1, Jitka" . "8"^^ . "2008-09-23+02:00"^^ . "Pilotn\u00ED 90ti denn\u00ED studie izomerizovan\u00E9ho chmelov\u00E9ho extraktu na potkanech" . . "C\u00EDlem studie bylo ov\u011B\u0159en\u00ED bezpe\u010Dnosti izomerizovan\u00E9ho chmelov\u00E9ho extraktu (IHE) z\u00EDskan\u00E9ho z chmelov\u00FDch \u0161i\u0161ek a srovn\u00E1n\u00ED s CO2 chmelov\u00FDm extraktem. Studie byla realizov\u00E1na na krys\u00E1ch. Podle vlastn\u00ED chuti konzumovaly krysy po 90 dn\u00ED standardn\u00ED dietu (kontroln\u00ED skupina 1), dietu s IHE obsahuj\u00EDc\u00ED 100 mg XN + IXN/kg (skupina 2), dietu obsahuj\u00EDc\u00ED 1000 mg XN + IXN/kg (skupina 3) nebo dietu obsahuj\u00EDc\u00ED 1000 mg CO2 chmelov\u00E9ho extraktu (skupina 4). Po 90 dnech byly krysy utraceny a jejich org\u00E1ny byly podrobeny anal\u00FDze. V\u00FDsledek: Extrakty z izomerizovan\u00E9ho i CO2 chmele nem\u011Bly vliv na funkci hlavn\u00EDch org\u00E1n\u016F. Oba extrakty v\u0161ak m\u011Bly vliv na antioxida\u010Dn\u00ED status krys. U skupin 3 a 4 byla nalezena sn\u00ED\u017Eena hladina GSH, u skupin 2,3 a 4 poklesla GPx aktivita a u skupiny 4 bylo zaznamen\u00E1na signifikantn\u011B zv\u00FD\u0161en\u00E1 ALT aktivita. U skupin 3 a 4 byl v porovn\u00E1n\u00ED s kontroln\u00ED skupinou zaznamen\u00E1n nesignifikantn\u00ED pokles celkov\u00E9 hmotnosti zv\u00ED\u0159at."@cs . . "RIV/60318287:_____/08:#0000015!RIV09-MPO-60318287" . . . . . "C\u00EDlem studie bylo ov\u011B\u0159en\u00ED bezpe\u010Dnosti izomerizovan\u00E9ho chmelov\u00E9ho extraktu (IHE) z\u00EDskan\u00E9ho z chmelov\u00FDch \u0161i\u0161ek a srovn\u00E1n\u00ED s CO2 chmelov\u00FDm extraktem. Studie byla realizov\u00E1na na krys\u00E1ch. Podle vlastn\u00ED chuti konzumovaly krysy po 90 dn\u00ED standardn\u00ED dietu (kontroln\u00ED skupina 1), dietu s IHE obsahuj\u00EDc\u00ED 100 mg XN + IXN/kg (skupina 2), dietu obsahuj\u00EDc\u00ED 1000 mg XN + IXN/kg (skupina 3) nebo dietu obsahuj\u00EDc\u00ED 1000 mg CO2 chmelov\u00E9ho extraktu (skupina 4). Po 90 dnech byly krysy utraceny a jejich org\u00E1ny byly podrobeny anal\u00FDze. V\u00FDsledek: Extrakty z izomerizovan\u00E9ho i CO2 chmele nem\u011Bly vliv na funkci hlavn\u00EDch org\u00E1n\u016F. Oba extrakty v\u0161ak m\u011Bly vliv na antioxida\u010Dn\u00ED status krys. U skupin 3 a 4 byla nalezena sn\u00ED\u017Eena hladina GSH, u skupin 2,3 a 4 poklesla GPx aktivita a u skupiny 4 bylo zaznamen\u00E1na signifikantn\u011B zv\u00FD\u0161en\u00E1 ALT aktivita. U skupin 3 a 4 byl v porovn\u00E1n\u00ED s kontroln\u00ED skupinou zaznamen\u00E1n nesignifikantn\u00ED pokles celkov\u00E9 hmotnosti zv\u00ED\u0159at." .