. "OBJECTIVES: HI-6 or asoxime in some sources is an antidotum for nerve agents. In recent experiments, implication of HI-6 in immunity response was proved; however, the issue was not studied in details. In this experiment, role of cytokines in HI-6 impact on immunity was searched. DESIGN: BALB/c mice were exposed to saline, HI-6 in a dose 1 - 100 mg/kg and/or 1 keyhole limpet hemocyanin (KLH) 1 mg/kg. Mice were sacrificed 21 days after experiment beginning and interleukins (IL) 1, 2, 4, 6 were determined by Enzyme Linked Immunosorbent Assay (ELISA). RESULTS: The animals had no pathological manifestation. From the tested cytokines, no significant alteration was found for the IL-1, IL-4 and IL-6. IL-2 was significantly increased in a dose response manner. CONCLUSIONS: The experimental data well correlates with the previous work where HI-6 caused increase of antibodies production. HI-6 is suitable to be used as an adjuvant whenever immunity should be pharmacologically altered."@en . "Neuroendocrinology Letters" . "acetylcholinesterase; cytokine; interleukin; cholinergic anti-inflammatory pathway; vaccination"@en . "0172-780X" . . "OBJECTIVES: HI-6 or asoxime in some sources is an antidotum for nerve agents. In recent experiments, implication of HI-6 in immunity response was proved; however, the issue was not studied in details. In this experiment, role of cytokines in HI-6 impact on immunity was searched. DESIGN: BALB/c mice were exposed to saline, HI-6 in a dose 1 - 100 mg/kg and/or 1 keyhole limpet hemocyanin (KLH) 1 mg/kg. Mice were sacrificed 21 days after experiment beginning and interleukins (IL) 1, 2, 4, 6 were determined by Enzyme Linked Immunosorbent Assay (ELISA). RESULTS: The animals had no pathological manifestation. From the tested cytokines, no significant alteration was found for the IL-1, IL-4 and IL-6. IL-2 was significantly increased in a dose response manner. CONCLUSIONS: The experimental data well correlates with the previous work where HI-6 caused increase of antibodies production. HI-6 is suitable to be used as an adjuvant whenever immunity should be pharmacologically altered." . . . "Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model"@en . . . . "35" . "Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model"@en . "13333" . "SE - \u0160v\u00E9dsk\u00E9 kr\u00E1lovstv\u00ED" . "P(LH11023)" . . "Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model" . "1"^^ . "Pohanka, Miroslav" . . "http://www.nel.edu/archive_issues/o/35_s2/35_s2_Pohanka_155-157.pdf" . "RIV/60162694:G44__/14:43875219" . "[B989E0308BD6]" . . "3"^^ . "000351064900020" . "RIV/60162694:G44__/14:43875219!RIV15-MSM-G44_____" . . "1"^^ . "Suppl 2" . . . "Effect of HI-6 on cytokines production after immunity stimulation by keyhole limpet hemocyanin in a mouse model" . . . . "G44" . .