. . "89346" . "Molekul\u00E1rn\u00ED epidemiologie viru varicella-zoster"@cs . "Molekul\u00E1rn\u00ED epidemiologie viru varicella-zoster" . . "[C977DBA0D945]" . "Molekul\u00E1rn\u00ED epidemiologie viru varicella-zoster" . . "24"^^ . "Molecular epidemiology of VZV"@en . . "3" . . "February" . "i-med" . "G44" . . "Bo\u0161t\u00EDkov\u00E1, Vanda" . "I" . . "SK - Slovensk\u00E1 republika" . "Molecular epidemiology of VZV"@en . "http://www.i-med.sk/moodle/" . . . "RIV/60162694:G44__/13:43875008" . "Varicella zoster virus belongs to a class of neurotrophic herpes virus. Characterized by a highly conserved genome , containing approximately 125 000 nucleotide bases (bp). Man is the only host and reservoir of this highly infectious pathogen. Primary infection manifests as acute exanthematous illnesses (itchy rash , fever , fatigue , malaise , headache ) , mostly in children under 10 years in temperate regions . In areas with high temperatures of the tropics , the disease occurs among the older population ( 18-35) - this phenomenon has not yet been elucidated. Relatively very serious disease in a healthy child can go to in a life-threatening issue (pneumonia , hepatitis , meningoencephalitis ) in the case of immunocompromised patients, pregnant women, patients with HIV infection , transplant patients , adults as well as infants . Localized bacterial superinfection caused by Staphylococci and Streptococci can cause sepsis , bacterial pneumonia, otitis media or necrotic tissue changes . Secondary infection manifests as herpes zoster (, under reactivation of the virus in the dorsal root ganglia , as a consequence of primary infection of varicella . Zoster is reflected back vesicular rash , whose incidence increases with age. 75 % of cases occur in patients over 45 years of age , with older people then half of them are more than likely complications , most acutely painful post-herpetic neuralgia . In immunosuppressed patients increases the risk disease in younger age groups , together with the possibility of repeated infections and severe course of the disease. Sequence data show that genetic diversity and epidemiology of VZV infection is influenced by the departure of disease , the nature of the climate in that area and population factors in the area . Study of genetic diversity of VZV may then have direct implications in both epidemiological and evolutionary analysis , and in defining potential genetic correlates of viral pathogenicity and resistance."@en . "RIV/60162694:G44__/13:43875008!RIV14-MO0-G44_____" . "1"^^ . . "1338-4392" . . "Varicella zoster virus pat\u0159\u00ED do skupiny neurotropn\u00EDch herpetick\u00FDch vir\u016F. Vyzna\u010Duje se vysoce konzervativn\u00EDm genomem, obsahuj\u00EDc\u00EDm p\u0159ibli\u017En\u011B 125 000 nukleotidov\u00FDch b\u00E1z\u00ED. \u010Clov\u011Bk je jedin\u00FDm hostitelem a rezervo\u00E1rem tohoto vysoce infek\u010Dn\u00EDho patogenu. Prim\u00E1rn\u00ED infekce se projevuje jako akutn\u00ED exant\u00E9mov\u00E9 onemocn\u011Bn\u00ED (sv\u011Bdiv\u00E1 vyr\u00E1\u017Eka, hore\u010Dka, \u00FAnava, celkov\u00E1 nevolnost, bolesti hlavy), p\u0159ev\u00E1\u017En\u011B u d\u011Bt\u00ED do 10 let v oblastech m\u00EDrn\u00E9ho p\u00E1su. V oblastech trop\u016F s vysok\u00FDmi teplotami se onemocn\u011Bn\u00ED vyskytuje mezi star\u0161\u00ED populac\u00ED (18-35)-tento jev nebyl dosud objasn\u011Bn. Relativn\u011B nep\u0159\u00EDli\u0161 z\u00E1va\u017En\u00E9 onemocn\u011Bn\u00ED u zdrav\u00E9ho d\u00EDt\u011Bte m\u016F\u017Ee p\u0159ej\u00EDt a\u017E v \u017Eivot ohro\u017Euj\u00EDc\u00ED z\u00E1le\u017Eitost (pneumonie, hepatitidy, meningoencefalitidy) v p\u0159\u00EDpad\u011B imunosuprimovan\u00FDch pacient\u016F, t\u011Bhotn\u00FDch \u017Een, pacient\u016F s HIV infekc\u00ED, pacient\u016F po transplantac\u00EDch, dosp\u011Bl\u00FDch jedinc\u016F, stejn\u011B jako kojenc\u016F. Lokalizovan\u00E1 bakteri\u00E1ln\u00ED superinfekce, vyvolan\u00E1 Staphylococci nebo Streptococci m\u016F\u017Ee zp\u016Fsobit septick\u00E9 stavy, bakteri\u00E1ln\u00ED pneumonii, otitis media \u010Di nekrotick\u00E9 zm\u011Bny tk\u00E1n\u00ED. Sekund\u00E1rn\u00ED VZV infekce se manifestuje jako herpes zoster, v r\u00E1mci reaktivace viru v dors\u00E1ln\u00EDch gangli\u00EDch, jako n\u00E1sledek prim\u00E1rn\u00ED infekce varicellou. Zoster se projevuje op\u011Bt vesikul\u00E1rn\u00EDm exant\u00E9mem, jeho\u017E incidence se zvy\u0161uje s nar\u016Fstaj\u00EDc\u00EDm v\u011Bkem pacienta. 75 % p\u0159\u00EDpad\u016F se vyskytuje u pacient\u016F nad 45 let, u star\u0161\u00EDch lid\u00ED pak u poloviny z nich jsou v\u00EDce ne\u017E pravd\u011Bpodobn\u00E9 komplikace, nej\u010Dast\u011Bji siln\u011B bolestiv\u00E1 postherpetick\u00E1 neuralgia. U imunosuprimovan\u00FDch pacient\u016F se zvy\u0161uje riziko zosterov\u00E9ho onemocn\u011Bn\u00ED i ve v\u011Bkov\u011B mlad\u0161\u00EDch skupin\u00E1ch, sou\u010Dasn\u011B i s mo\u017Enost\u00ED opakovan\u00FDch infekc\u00ED a t\u011B\u017Ek\u00FDch pr\u016Fb\u011Bh\u016F nemoci. Sekven\u010Dn\u00ED data ukazuj\u00ED, \u017Ee genetick\u00E1 diversita a epidemiologie infekce VZV je ovliv\u0148ov\u00E1na m\u00EDstem v\u00FDskytu onemocn\u011Bn\u00ED, charakterem klimatu v dan\u00E9 lokalit\u011B a popula\u010Dn\u00EDmi faktory v oblasti. Studium genetick\u00E9 diverzity VZV pak m\u016F\u017Ee m\u00EDt p\u0159\u00EDm\u00E9 implikace jak v epidemiologick\u00E9 a evolu\u010Dn\u00ED anal\u00FDze, tak i v mo\u017En\u00E9mu definov\u00E1n\u00ED genetick\u00FDch korel\u00E1t\u016F virov\u00E9 patogenicity \u010Di rezistence."@cs . "Molekul\u00E1rn\u00ED epidemiologie viru varicella-zoster"@cs . . "VZV; epidemiology; Molecular"@en . "1"^^ . "Varicella zoster virus pat\u0159\u00ED do skupiny neurotropn\u00EDch herpetick\u00FDch vir\u016F. Vyzna\u010Duje se vysoce konzervativn\u00EDm genomem, obsahuj\u00EDc\u00EDm p\u0159ibli\u017En\u011B 125 000 nukleotidov\u00FDch b\u00E1z\u00ED. \u010Clov\u011Bk je jedin\u00FDm hostitelem a rezervo\u00E1rem tohoto vysoce infek\u010Dn\u00EDho patogenu. Prim\u00E1rn\u00ED infekce se projevuje jako akutn\u00ED exant\u00E9mov\u00E9 onemocn\u011Bn\u00ED (sv\u011Bdiv\u00E1 vyr\u00E1\u017Eka, hore\u010Dka, \u00FAnava, celkov\u00E1 nevolnost, bolesti hlavy), p\u0159ev\u00E1\u017En\u011B u d\u011Bt\u00ED do 10 let v oblastech m\u00EDrn\u00E9ho p\u00E1su. V oblastech trop\u016F s vysok\u00FDmi teplotami se onemocn\u011Bn\u00ED vyskytuje mezi star\u0161\u00ED populac\u00ED (18-35)-tento jev nebyl dosud objasn\u011Bn. Relativn\u011B nep\u0159\u00EDli\u0161 z\u00E1va\u017En\u00E9 onemocn\u011Bn\u00ED u zdrav\u00E9ho d\u00EDt\u011Bte m\u016F\u017Ee p\u0159ej\u00EDt a\u017E v \u017Eivot ohro\u017Euj\u00EDc\u00ED z\u00E1le\u017Eitost (pneumonie, hepatitidy, meningoencefalitidy) v p\u0159\u00EDpad\u011B imunosuprimovan\u00FDch pacient\u016F, t\u011Bhotn\u00FDch \u017Een, pacient\u016F s HIV infekc\u00ED, pacient\u016F po transplantac\u00EDch, dosp\u011Bl\u00FDch jedinc\u016F, stejn\u011B jako kojenc\u016F. Lokalizovan\u00E1 bakteri\u00E1ln\u00ED superinfekce, vyvolan\u00E1 Staphylococci nebo Streptococci m\u016F\u017Ee zp\u016Fsobit septick\u00E9 stavy, bakteri\u00E1ln\u00ED pneumonii, otitis media \u010Di nekrotick\u00E9 zm\u011Bny tk\u00E1n\u00ED. Sekund\u00E1rn\u00ED VZV infekce se manifestuje jako herpes zoster, v r\u00E1mci reaktivace viru v dors\u00E1ln\u00EDch gangli\u00EDch, jako n\u00E1sledek prim\u00E1rn\u00ED infekce varicellou. Zoster se projevuje op\u011Bt vesikul\u00E1rn\u00EDm exant\u00E9mem, jeho\u017E incidence se zvy\u0161uje s nar\u016Fstaj\u00EDc\u00EDm v\u011Bkem pacienta. 75 % p\u0159\u00EDpad\u016F se vyskytuje u pacient\u016F nad 45 let, u star\u0161\u00EDch lid\u00ED pak u poloviny z nich jsou v\u00EDce ne\u017E pravd\u011Bpodobn\u00E9 komplikace, nej\u010Dast\u011Bji siln\u011B bolestiv\u00E1 postherpetick\u00E1 neuralgia. U imunosuprimovan\u00FDch pacient\u016F se zvy\u0161uje riziko zosterov\u00E9ho onemocn\u011Bn\u00ED i ve v\u011Bkov\u011B mlad\u0161\u00EDch skupin\u00E1ch, sou\u010Dasn\u011B i s mo\u017Enost\u00ED opakovan\u00FDch infekc\u00ED a t\u011B\u017Ek\u00FDch pr\u016Fb\u011Bh\u016F nemoci. Sekven\u010Dn\u00ED data ukazuj\u00ED, \u017Ee genetick\u00E1 diversita a epidemiologie infekce VZV je ovliv\u0148ov\u00E1na m\u00EDstem v\u00FDskytu onemocn\u011Bn\u00ED, charakterem klimatu v dan\u00E9 lokalit\u011B a popula\u010Dn\u00EDmi faktory v oblasti. Studium genetick\u00E9 diverzity VZV pak m\u016F\u017Ee m\u00EDt p\u0159\u00EDm\u00E9 implikace jak v epidemiologick\u00E9 a evolu\u010Dn\u00ED anal\u00FDze, tak i v mo\u017En\u00E9mu definov\u00E1n\u00ED genetick\u00FDch korel\u00E1t\u016F virov\u00E9 patogenicity \u010Di rezistence." . .