. "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "1742-7835" . "000309921600007" . . . . . "RIV/60162694:G44__/12:43874582" . "I" . "120103" . "3"^^ . "RIV/60162694:G44__/12:43874582!RIV13-MO0-G44_____" . "3"^^ . . . "Mis\u00EDk, Jan" . . "A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats" . . "111" . "Kassa, Ji\u0159\u00ED" . . . "A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats"@en . . . . "The neuroprotective effects of a newly developed oxime K203 and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with sarin were studied. The sarin-induced neurotoxicity was monitored using a functional observatory battery at 2 similar to hr after sarin challenge. The results indicate that the potency of a novel bispyridinium oxime K203 to counteract sarin-induced neurotoxicity is relatively low and roughly corresponds to the neuroprotective efficacy of obidoxime. Among tested oximes, the oxime HI-6 seems to be significanlty more efficacious to counteract acute neurotoxicity of sarin than commonly used obidoxime and a newly developed oxime K203. Thus, the oxime K203 does not provide any beneficial effect for the antidotal treatment of acute poisoning with sarin in comparison with the oxime HI-6 that should be considered to be the best oxime for antidotal treatment of acute sarin poisonings." . . "6"^^ . "[9392398BC732]" . "A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats"@en . "10.1111/j.1742-7843.2012.00897.x" . . "The neuroprotective effects of a newly developed oxime K203 and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with sarin were studied. The sarin-induced neurotoxicity was monitored using a functional observatory battery at 2 similar to hr after sarin challenge. The results indicate that the potency of a novel bispyridinium oxime K203 to counteract sarin-induced neurotoxicity is relatively low and roughly corresponds to the neuroprotective efficacy of obidoxime. Among tested oximes, the oxime HI-6 seems to be significanlty more efficacious to counteract acute neurotoxicity of sarin than commonly used obidoxime and a newly developed oxime K203. Thus, the oxime K203 does not provide any beneficial effect for the antidotal treatment of acute poisoning with sarin in comparison with the oxime HI-6 that should be considered to be the best oxime for antidotal treatment of acute sarin poisonings."@en . "5" . . "MICE; BLOOD; ACETYLCHOLINESTERASE; BRAIN; NERVE AGENTS; PYRIDINIUM OXIMES; ANTIDOTAL TREATMENT; ORGANOPHOSPHORUS COMPOUNDS; NEUROPROTECTIVE EFFICACY; TABUN-POISONED RATS"@en . "http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2012.00897.x/full" . "\u017D\u010F\u00E1rov\u00E1 Karasov\u00E1, Jana" . "G44" . "Basic & Clinical Pharmacology & Toxicology" . . "A comparison of the potency of a novel bispyridinium oxime K203 and currently available oximes (obidoxime, HI-6) to counteract the acute neurotoxicity of sarin in rats" . . . . . .