. "000296025900071" . "RIV/60162694:G44__/11:00002428" . . "Horov\u00E1, Anna" . "Opletalov\u00E1, Veronika" . "Ku\u010Da, Kamil" . "Holas, Ond\u0159ej" . "0960-894X" . . . "Zemek, Filip" . . "http://dx.doi.org/10.1016/j.bmcl.2011.08.042" . . . "Cholinesterase inhibitors are, so far, the only successful strategy for the symptomatic treatment of Alzheimer's disease. Tacrine (THA) is a potent acetylcholinesterase inhibitor that was used in the treatment of Alzheimer's disease for a long time. However, the clinical use of THA was hampered by its low therapeutic index, short half-life and liver toxicity. 7-methoxytacrine (7-MEOTA) is equally pharmacological active compound with lower toxicity compared to THA. In this paper, the synthesis, biological activity and molecular modelling of elimination by-product isolated during synthesis of 7-MEOTA based bis-alkylene linked compound is described."@en . "Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties" . . "[06A420AD599A]" . "G44" . "Cholinesterase inhibitors are, so far, the only successful strategy for the symptomatic treatment of Alzheimer's disease. Tacrine (THA) is a potent acetylcholinesterase inhibitor that was used in the treatment of Alzheimer's disease for a long time. However, the clinical use of THA was hampered by its low therapeutic index, short half-life and liver toxicity. 7-methoxytacrine (7-MEOTA) is equally pharmacological active compound with lower toxicity compared to THA. In this paper, the synthesis, biological activity and molecular modelling of elimination by-product isolated during synthesis of 7-MEOTA based bis-alkylene linked compound is described." . "233871" . . . . "Hroudov\u00E1, Jana" . . "inhibition selectivity; molecular modelling; butyrylcholinesterase; Alzheimer disease; acetylcholinesterase; 7-methoxytacrine"@en . "10.1016/j.bmcl.2011.08.042" . "Fi\u0161ar, Zden\u011Bk" . . "Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties"@en . "Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties" . . "Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties"@en . . "11"^^ . "Bioorganic & Medicinal Chemistry Letters" . "4"^^ . "Kor\u00E1be\u010Dn\u00FD, Jan" . . "21" . . "RIV/60162694:G44__/11:00002428!RIV13-GA0-G44_____" . . "3"^^ . . . "Mus\u00EDlek, Kamil" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "P(GAP303/11/1907), S, Z(MSM0021620849)" . "21" . . "Jung, Young-Sik" . . "Nepovimova, Eugenie" .