. "I, S" . "Dohnal, Vlastimil" . "RIV/60162694:G44__/10:00002358" . . "5"^^ . . "Ku\u010Da, Kamil" . "Huang, Lingli" . "G44" . . . "18"^^ . . "Drug Metabolism Reviews" . "2" . . "Metabolic pathways of trichothecenes" . "Metabolic pathways of trichothecenes"@en . "Wu, Qinghua" . "Metabolic pathways of trichothecenes"@en . "Trichothecenes; metabolic pathways; biodegradation; Fusarium; animals; human"@en . . "Metabolic pathways of trichothecenes" . . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "[2797912350CB]" . . "Yuan, Zonghui" . . "000276765900002" . "Trichothecenes are a group of mycotoxins mainly produced by the fungi of Fusarium genus. Consumers are particularly concerned over the toxicity and food safety of trichothecenes and their metabolites from food-producing animals. The metabolism of T-2 toxin, deoxynivalenol (DON), nivalenol (NIV), fusarenon-X (FX), diacetoxyscirpenol (DAS), 3-acetyldeoxy-nivalenol (3-aDON), and 15-acetyldeoxynivalenol (15-aDON) in rodents, swine, ruminants, poultry, and humans are reviewed in this article. Metabolic pathways of these mycotoxins are very different. The major metabolic pathways of T-2 toxin in animals are hydrolysis, hydroxylation, de-epoxidation, and conjugation. After being transformed to HT-2 toxin, it undergoes further hydroxylation at C-3? to yield 3?-hydroxy-HT-2 toxin, which is considered as an activation pathway, whereas transformation from T-2 to T-2 tetraol is an inactivation pathway in animals. The typical metabolites of T-2 toxin in animals are HT-2 toxin, T-2 triol, T-2 tetraol, neosolaniol (" . "42" . . . "270557" . "1"^^ . "0360-2532" . "Trichothecenes are a group of mycotoxins mainly produced by the fungi of Fusarium genus. Consumers are particularly concerned over the toxicity and food safety of trichothecenes and their metabolites from food-producing animals. The metabolism of T-2 toxin, deoxynivalenol (DON), nivalenol (NIV), fusarenon-X (FX), diacetoxyscirpenol (DAS), 3-acetyldeoxy-nivalenol (3-aDON), and 15-acetyldeoxynivalenol (15-aDON) in rodents, swine, ruminants, poultry, and humans are reviewed in this article. Metabolic pathways of these mycotoxins are very different. The major metabolic pathways of T-2 toxin in animals are hydrolysis, hydroxylation, de-epoxidation, and conjugation. After being transformed to HT-2 toxin, it undergoes further hydroxylation at C-3? to yield 3?-hydroxy-HT-2 toxin, which is considered as an activation pathway, whereas transformation from T-2 to T-2 tetraol is an inactivation pathway in animals. The typical metabolites of T-2 toxin in animals are HT-2 toxin, T-2 triol, T-2 tetraol, neosolaniol ("@en . . "RIV/60162694:G44__/10:00002358!RIV11-MO0-G44_____" . .