. "288807" . "90" . "pancreatic cancer; partial pancreaticoduodenectomy; jaundice; prognosis"@en . . "G44" . "Current review of the diagnosis and treatment of pancreatic cancer"@en . . "[1FC709E290A6]" . . "5"^^ . "Sou\u010Dasn\u00FD pohled na diagnostiku a l\u00E9\u010Dbu karcinomu slinivky b\u0159i\u0161n\u00ED" . . . . "\u0160ubrt, Zden\u011Bk" . . "Ka\u0161ka, Milan" . . . . "Sou\u010Dasn\u00FD pohled na diagnostiku a l\u00E9\u010Dbu karcinomu slinivky b\u0159i\u0161n\u00ED"@cs . "Current review of the diagnosis and treatment of pancreatic cancer"@en . "\u010Ce\u010Dka, Filip" . "Karcinom slinivky b\u0159i\u0161n\u00ED je onemocn\u011Bn\u00ED se z\u00E1va\u017Enou progn\u00F3zou. Jeho incidence v sou\u010Dasn\u00E9 dob\u011B stoup\u00E1 a v \u010Cesk\u00E9 republice se \u0159ad\u00ED na \u010Dtvrt\u00E9 m\u00EDsto mezi p\u0159i\u010Diny \u00FAmrt\u00ED na n\u00E1dorov\u00E9 onemocn\u011Bn\u00ED. Nej\u010Dast\u011Bji se projev\u00ED bezbolestn\u00FDm ikterem, mezi dal\u0161\u00ED p\u0159\u00EDznaky pat\u0159\u00ED zvracen\u00ED, bolesti v epigastriu, hubnut\u00ED, nechutenstv\u00ED nebo nov\u011B vznikl\u00FD diabetes mellitus. Diagnostika je zalo\u017Eena na zobrazovac\u00EDch metod\u00E1ch (UZ, CT, EUS). Nejv\u00FDznamn\u011Bj\u0161\u00ED onkomarker v diagnostice a sledov\u00E1n\u00ED v r\u00E1mci dispenzarizace je karbohydr\u00E1t antigen 19-9 (CA 19-9). V l\u00E9\u010Db\u011B m\u00E1 z\u00E1sadn\u00ED v\u00FDznam chirurgick\u00E1 resekce, kter\u00E1 je jedin\u00E1 potenci\u00E1ln\u011B kurativn\u00ED metoda. Adjuvantn\u00ED nebo paliativn\u00ED chemoterapie zlep\u0161uje kvalitu \u017Eivota a prodlu\u017Euje p\u0159e\u017Eit\u00ED pacient\u016F. Lok\u00E1ln\u011B pokro\u010Dil\u00E9 nebo diseminovan\u00E9 onemocn\u011Bn\u00ED m\u00E1 hor\u0161\u00ED progn\u00F3zu. Medi\u00E1n p\u0159e\u017Eit\u00ED pacient\u016F s neresekabiln\u00EDm karcinomem je 6-10 m\u011Bs\u00EDc\u016F, po radik\u00E1ln\u00ED resekci je p\u0159ibli\u017En\u011B 16-20 m\u011Bs\u00EDc\u016F. Proto je nutn\u00E9 p\u0159i podez\u0159en\u00ED na karcinom slinivky b\u0159i\u0161n\u00ED pacienty co nejd\u0159\u00EDve odeslat na specializovan\u00E1 pracovi\u0161t\u011B, dok" . . "0032-6739" . "CZ - \u010Cesk\u00E1 republika" . . . "RIV/60162694:G44__/10:00002330!RIV11-MO0-G44_____" . "Karcinom slinivky b\u0159i\u0161n\u00ED je onemocn\u011Bn\u00ED se z\u00E1va\u017Enou progn\u00F3zou. Jeho incidence v sou\u010Dasn\u00E9 dob\u011B stoup\u00E1 a v \u010Cesk\u00E9 republice se \u0159ad\u00ED na \u010Dtvrt\u00E9 m\u00EDsto mezi p\u0159i\u010Diny \u00FAmrt\u00ED na n\u00E1dorov\u00E9 onemocn\u011Bn\u00ED. Nej\u010Dast\u011Bji se projev\u00ED bezbolestn\u00FDm ikterem, mezi dal\u0161\u00ED p\u0159\u00EDznaky pat\u0159\u00ED zvracen\u00ED, bolesti v epigastriu, hubnut\u00ED, nechutenstv\u00ED nebo nov\u011B vznikl\u00FD diabetes mellitus. Diagnostika je zalo\u017Eena na zobrazovac\u00EDch metod\u00E1ch (UZ, CT, EUS). Nejv\u00FDznamn\u011Bj\u0161\u00ED onkomarker v diagnostice a sledov\u00E1n\u00ED v r\u00E1mci dispenzarizace je karbohydr\u00E1t antigen 19-9 (CA 19-9). V l\u00E9\u010Db\u011B m\u00E1 z\u00E1sadn\u00ED v\u00FDznam chirurgick\u00E1 resekce, kter\u00E1 je jedin\u00E1 potenci\u00E1ln\u011B kurativn\u00ED metoda. Adjuvantn\u00ED nebo paliativn\u00ED chemoterapie zlep\u0161uje kvalitu \u017Eivota a prodlu\u017Euje p\u0159e\u017Eit\u00ED pacient\u016F. Lok\u00E1ln\u011B pokro\u010Dil\u00E9 nebo diseminovan\u00E9 onemocn\u011Bn\u00ED m\u00E1 hor\u0161\u00ED progn\u00F3zu. Medi\u00E1n p\u0159e\u017Eit\u00ED pacient\u016F s neresekabiln\u00EDm karcinomem je 6-10 m\u011Bs\u00EDc\u016F, po radik\u00E1ln\u00ED resekci je p\u0159ibli\u017En\u011B 16-20 m\u011Bs\u00EDc\u016F. Proto je nutn\u00E9 p\u0159i podez\u0159en\u00ED na karcinom slinivky b\u0159i\u0161n\u00ED pacienty co nejd\u0159\u00EDve odeslat na specializovan\u00E1 pracovi\u0161t\u011B, dok"@cs . . "V, Z(MZ0FNHK2005)" . . "Jon, Bohumil" . "Ferko, Alexander" . . "Praktick\u00FD l\u00E9ka\u0159" . "Sou\u010Dasn\u00FD pohled na diagnostiku a l\u00E9\u010Dbu karcinomu slinivky b\u0159i\u0161n\u00ED" . "4"^^ . . "Pancreatic cancer has dismal prognosis. Its incidence in the Czech Republic is rising and it is currently the fourth most common cause of cancer related death. The most common presenting symptom is painless jaundice. Other symptoms include vomiting, epigastric pain, anorexia or diabetes mellitus. Diagnosis is based on imaging methods (ultrasound, CT, endosonography). Surgical resection is the most significant treatment method and the only potentially curative method. Adjuvant and palliative chemotherapy improve quality of life and prolong patient survival. Therefore it is necessary to finish the diagnostic process and commence appropriate treatment in a specialized centre as soon as possible."@en . "RIV/60162694:G44__/10:00002330" . "2"^^ . "10" . "Sou\u010Dasn\u00FD pohled na diagnostiku a l\u00E9\u010Dbu karcinomu slinivky b\u0159i\u0161n\u00ED"@cs .