"Synthesis and in vitro evaluation of N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment" . "Mus\u00EDlek, Kamil" . . . "Kor\u00E1be\u010Dn\u00FD, Jan" . . "G44" . . "Fi\u0161ar, Zden\u011Bk" . "Holas, Ond\u0159ej" . . "15" . "A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. Its inhibitory ability towards cholinesterases was determined and compared to tacrine (THA) and 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA). The assessment of IC50 values revealed 1 as a weak inhibitor of both tested enzymes." . . "Marek, Jan" . "CH - \u0160v\u00FDcarsk\u00E1 konfederace" . "1420-3049" . . "14"^^ . "Patocka, Ji\u0159\u00ED" . . "000285709000019" . "Synthesis and in vitro evaluation of N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment" . . "4"^^ . . . "9"^^ . "P(OVUOFVZ200805), S, Z(MSM0021620822)" . "Zemek, Filip" . "Molecules" . "Ku\u010Da, Kamil" . "Nachon, Florian" . "Dohnal, Vlastimil" . "RIV/60162694:G44__/10:00002300!RIV11-MO0-G44_____" . "291483" . "RIV/60162694:G44__/10:00002300" . . . "Opletalov\u00E1, Veronika" . "Synthesis and in vitro evaluation of N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment"@en . . . "A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. Its inhibitory ability towards cholinesterases was determined and compared to tacrine (THA) and 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA). The assessment of IC50 values revealed 1 as a weak inhibitor of both tested enzymes."@en . "Nepovimov\u00E1, Eugenie" . . . "tacrine; acetylcholinesterase; butyrylcholinesterase; 7-MEOTA; inhibition; Alzheimer disease"@en . . "Synthesis and in vitro evaluation of N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment"@en . "Jun, Daniel" . "12" . . "[E246040EDCAE]" . . . . . . "Hroudov\u00E1, Jana" .