. . . . . "291482" . "Opletalov\u00E1, Veronika" . . "RIV/60162694:G44__/10:00002299" . "acetylcholinesterase; butyrylcholinesterase; Alzheimer disease; tacrine; 7-MEOTA; inhibition"@en . "Bioorganic & Medicinal Chemistry Letters" . "20" . "Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease" . "Ku\u010Da, Kamil" . . . "Dohnal, Vlastimil" . "Kor\u00E1be\u010Dn\u00FD, Jan" . . "Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease"@en . "Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease"@en . "Mus\u00EDlek, Kamil" . . . "In this paper, series of 7-MEOTA analogues (N-alkyl-7-methoxytacrine) were synthesized. Their inhibitory ability was evaluated on recombinant human acetylcholinesterase (AChE) and plasmatic human butyrylcholinesterase (BChE). Three novel compounds showed promising results towards hAChE better to THA or 7-MEOTA. Three compounds resulted as potent inhibitors of hBChE. The SAR findings highlighted the C6-C7 N-alkyl chains for cholinesterase inhibition."@en . . "Zemek, Filip" . . . "RIV/60162694:G44__/10:00002299!RIV11-MO0-G44_____" . . . "Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease" . . "Binder, Ji\u0159\u00ED" . "20" . . "000281963700030" . "10"^^ . "[8D32DCD8C62F]" . "Marek, Jan" . "5"^^ . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "G44" . . . "0960-894X" . . "3"^^ . "Pohanka, Miroslav" . . "P(OVUOFVZ200805), S" . . "In this paper, series of 7-MEOTA analogues (N-alkyl-7-methoxytacrine) were synthesized. Their inhibitory ability was evaluated on recombinant human acetylcholinesterase (AChE) and plasmatic human butyrylcholinesterase (BChE). Three novel compounds showed promising results towards hAChE better to THA or 7-MEOTA. Three compounds resulted as potent inhibitors of hBChE. The SAR findings highlighted the C6-C7 N-alkyl chains for cholinesterase inhibition." . "Holas, Ond\u0159ej" .