"Mus\u00EDlek, Kamil" . "4" . "7" . "Ku\u010Da, Kamil" . "291484" . "Kor\u00E1be\u010Dn\u00FD, Jan" . "Pohanka, Miroslav" . . . . . . . . "Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA" . . . . . "RIV/60162694:G44__/10:00002297" . "G44" . "Dohnal, Vlastimil" . "P(OVUOFVZ200805), S, Z(MSM0021620822)" . . . . . . "3"^^ . "Holas, Ond\u0159ej" . "Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA" . "RIV/60162694:G44__/10:00002297!RIV11-MO0-G44_____" . "acetylcholinesterase; butyrylcholinesterase; Alzheimer`s disease; tacrine; inhibition selectivity"@en . . "Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA"@en . . "1570-1786" . "000277156500011" . "Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized - namely - 9,9`-di-(alkane-1,omega-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article."@en . "AE - St\u00E1t Spojen\u00E9 arabsk\u00E9 emir\u00E1ty" . . "[165C52A24E2F]" . . "7"^^ . "Letters in Organic Chemistry" . "Opletalov\u00E1, Veronika" . "Formerly, 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine (7-MEOTA) was investigated as promising tacrine analogue beneficial for its low toxicity compared to tacrine. In this study, novel 7-MEOTA derivatives were synthesized - namely - 9,9`-di-(alkane-1,omega-diyldiimino)-di-(7-methoxy-1,2,3,4-tetrahydroacridine) was prepared from the corresponding diiodoalkanes. The novel compounds exhibit anticholinesterase (acetylcholinesterase and butyrylcholinesterase) activity in vitro. The synthesis and in vitro data are summarized in this article." . . "5"^^ . . "Synthesis and in vitro evaluation of new tacrine derivates-bis-alkylene linked 7-MEOTA"@en .