"RIV/60162694:G44__/09:00002423" . "Mus\u00EDlek, Kamil" . "Evaluation of oxime K203 as antidote in tabun poisoning"@en . "Berend, S." . . "RIV/60162694:G44__/09:00002423!RIV11-MO0-G44_____" . "2"^^ . "Radic, B." . . "Evaluation of oxime K203 as antidote in tabun poisoning"@en . "HR - Chorvatsk\u00E1 republika" . "We studied bispyridinium oxime K203 with tabun-inhibited human AChE and BChE in vitro, and its antidotal effect on tabun-poisoned mice and rats in vivo. We compared it with oximes K048 and TMB-4, which have proven the most efficient oxime antidotes in tabun poisoning by now. Tabun-inhibited AChE was completely reactivated by K203, with the overall reactivation rate constant of 1806 L mol(-1) min(-1). This means that K203 is a very potent reactivator of tabun-inhibited AChE. In addition, K203 reversibly inhibited AChE (Ki = 0.090 mmol L(-1)) and BChE (K(i) = 0.91 mmol L(-1)), and exhibited its protective effect against phosphorylation of AChE by tabun in vitro. In vivo, a quarter of the LD50 K203 dose insured survival of all mice after the application of as many as 8 LD50 doses of tabun, which is the highest dosage obtained compared to K048 and TMB-4. This therapeutic improvement obtained by K203 in tabun-poisoning places this oxime in the spotlight for further development." . "[D0C2D4B02747]" . . . . "acetylcholinesterase; bioscavenger; butyrylcholinesterase; K048; nerve agents; TMB-4; pyridinium oxime"@en . "Archives of Industrial Hygiene and Toxicology" . . "8"^^ . "N" . . . "Kovarik, Zrinka" . . "0004-1254" . . . . . . "1" . "60" . "Lucic Vrdoljak, A." . . "Evaluation of oxime K203 as antidote in tabun poisoning" . "Calic, M." . "7"^^ . . . "G44" . . "We studied bispyridinium oxime K203 with tabun-inhibited human AChE and BChE in vitro, and its antidotal effect on tabun-poisoned mice and rats in vivo. We compared it with oximes K048 and TMB-4, which have proven the most efficient oxime antidotes in tabun poisoning by now. Tabun-inhibited AChE was completely reactivated by K203, with the overall reactivation rate constant of 1806 L mol(-1) min(-1). This means that K203 is a very potent reactivator of tabun-inhibited AChE. In addition, K203 reversibly inhibited AChE (Ki = 0.090 mmol L(-1)) and BChE (K(i) = 0.91 mmol L(-1)), and exhibited its protective effect against phosphorylation of AChE by tabun in vitro. In vivo, a quarter of the LD50 K203 dose insured survival of all mice after the application of as many as 8 LD50 doses of tabun, which is the highest dosage obtained compared to K048 and TMB-4. This therapeutic improvement obtained by K203 in tabun-poisoning places this oxime in the spotlight for further development."@en . "Ku\u010Da, Kamil" . . "313895" . "Evaluation of oxime K203 as antidote in tabun poisoning" .