. "4"^^ . . . . . . "The toxic effect of organophosphates is attributed to irreversible inhibition acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agent - Russian VX (RVX; N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD50 dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butyrylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 30% and 15% at 30 min. While AChE and BChE activities were reduced only 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potent inhibits ChE outsider the central nervous system."@en . "[49A3257B715E]" . . "Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX" . "4" . "The toxic effect of organophosphates is attributed to irreversible inhibition acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agent - Russian VX (RVX; N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD50 dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butyrylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 30% and 15% at 30 min. While AChE and BChE activities were reduced only 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potent inhibits ChE outsider the central nervous system." . "S, Z(MO0FVZ0000604)" . "Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX"@en . "5"^^ . "Bajgar, Ji\u0159\u00ED" . "G44" . . "Russian VX; acetylcholinesterase; butyrylcholinesterase; nerve agent"@en . "1029-8428" . . . . "16" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Ku\u010Da, Kamil" . . "RIV/60162694:G44__/09:00002130!RIV10-MO0-G44_____" . "RIV/60162694:G44__/09:00002130" . "\u017D\u010F\u00E1rov\u00E1 Karasov\u00E1, Jana" . . "Jun, Daniel" . . . "Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX" . "Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX"@en . . "000271028000002" . . . "5"^^ . . "Pavlikova, R\u016F\u017Eena" . "346365" . "Neurotoxicity Research" .