"Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available oximes (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats. Oximes were given at doses of 5% their LD50 along with 21 mg/kg atropine 5 min before the LD50 of cyclosarin (120 ug/kg). Blood and brain samples were collected 30 minutes later. The greatest difference between acetylcholinesterase inhibition in blood of cyclosarin-treated rats was found after administration of HI-6 (40%), compared to 22% for trimedoxime and 6% for obidoxime. Only 2 of the 7 newly synthesized oximes had any effect (K203 at 7%, K156 at 5%). Effective oximes against cyclosarin-inhibited plasma butyrylcholinesterase were HI-6 (42%), trimedoxime (11%), and K156 (4%). The oximes were less effective in brain than in blood, with reactivation values for HI-6 30% against acetylcholinesterase and 10% against butyrylcholinesterase. Values for newly synt" . . . "CH - \u0160v\u00FDcarsk\u00E1 konfederace" . "1422-0067" . . "Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats"@en . "RIV/60162694:G44__/09:00002128" . "Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats" . "Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats"@en . . "\u017D\u010F\u00E1rov\u00E1 Karasov\u00E1, Jana" . . "G44" . "acetylcholinesterase; butyrylcholinesterase; reactivators; oximes; cyclosarin"@en . "000268317300013" . "Pohanka, Miroslav" . "6"^^ . . "7" . "Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats" . "Mus\u00EDlek, Kamil" . . . . . "Ku\u010Da, Kamil" . . . "Z(MO0FVZ0000501)" . "10" . "Kassa, Ji\u0159\u00ED" . "Novotn\u00FD, Ladislav" . "6"^^ . "312253" . . "Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available oximes (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats. Oximes were given at doses of 5% their LD50 along with 21 mg/kg atropine 5 min before the LD50 of cyclosarin (120 ug/kg). Blood and brain samples were collected 30 minutes later. The greatest difference between acetylcholinesterase inhibition in blood of cyclosarin-treated rats was found after administration of HI-6 (40%), compared to 22% for trimedoxime and 6% for obidoxime. Only 2 of the 7 newly synthesized oximes had any effect (K203 at 7%, K156 at 5%). Effective oximes against cyclosarin-inhibited plasma butyrylcholinesterase were HI-6 (42%), trimedoxime (11%), and K156 (4%). The oximes were less effective in brain than in blood, with reactivation values for HI-6 30% against acetylcholinesterase and 10% against butyrylcholinesterase. Values for newly synt"@en . "[8A5EE32CEFF1]" . . . . "International Journal of Molecular Sciences" . . "RIV/60162694:G44__/09:00002128!RIV11-MO0-G44_____" . . . . . "11"^^ . .