"New performance of biosensor technology for Alzheimer\u00B4s disease drugs: in vitro comparison of tacrine and 7-methoxytacrine" . "RIV/60162694:G44__/08:00001993!RIV09-MO0-G44_____" . "Dv\u011B l\u00E9\u010Diva byly testov\u00E1ny elektrochmick\u00FDm biosenzorem s imobilizovanou acetylcholinester\u00E1zou (AChE). Prvn\u00ED byl takrin (zn\u00E1m jako Cognex) pou\u017E\u00EDvan\u00FD pro symptomatickou l\u00E9\u010Dbu AD. Druh\u00FD byl 7- methoxy deriv\u00E1t (7-MEOTA), kter\u00FD nebyl dosud komercializov\u00E1n. Byla ur\u010Dena hodnota IC50 (6.67+/-0.92)x10-7 M pro takrin a (1.66+/-1.43)x10-9 M pro 7-MEOTA. 7-MEOTA se zd\u00E1 b\u00FDt siln\u011Bj\u0161\u00ED inhibitor AChE a t\u00EDmto zp\u016Fsobem m\u016F\u017Ee b\u00FDt vhodn\u011Bj\u0161\u00ED pro l\u00E9\u010Dbu AD. Na\u0161e studie p\u0159edstavila biosenzor jako jednoduchou, levnou, ale precizn\u00ED metodu pro in vitro testov\u00E1n\u00ED potenci\u00E1ln\u00EDch l\u00E9\u010Div na AD."@cs . "Two drugs were tested using electrochemical biosensor with immobilized acetylcholinesterase (AChE). The first was commercialized drug tacrine (known also as Cognex) used for treatment of cognitive manifestation of Alzheimer\u00B4s disease (AD). The second one was its 7-methoxy derivate (7-MEOTA) that has not been marketed. We determined the IC50 (6.67+/-0.92)x10-7 M for tacrine and (1.66+/-1.43)x10-9 M for 7-MEOTA. In this in vitro study, 7-MEOTA acts as stronger inhibitor of AChE and in this way could be more favorable for treatment of cognitive manifestation of AD. Our study shows that biosensor technology could be used as a quick and cheap tool for testing of promising AChE inhibitors (AD drug candidates)." . . "Nov\u00E9 pou\u017Eit\u00ED biosenzoru pro testov\u00E1n\u00ED l\u00E9k\u016F pro Alzheimerovu chorobu: srovn\u00E1n\u00ED takrinu a 7metoxytakrinu"@cs . . "3"^^ . "RIV/60162694:G44__/08:00001993" . . "29" . "New performance of biosensor technology for Alzheimer\u00B4s disease drugs: in vitro comparison of tacrine and 7-methoxytacrine"@en . "Alzheimer\u00B4s disease; cognex, tacrine; 7-methoxytacrine; cholinesterase; 7-MEOTA; biosensor; inhibition"@en . . . . "3"^^ . . "Neuroendocrinology Letters" . "Z(MO0FVZ0000604)" . . "G44" . . . "Nov\u00E9 pou\u017Eit\u00ED biosenzoru pro testov\u00E1n\u00ED l\u00E9k\u016F pro Alzheimerovu chorobu: srovn\u00E1n\u00ED takrinu a 7metoxytakrinu"@cs . "New performance of biosensor technology for Alzheimer\u00B4s disease drugs: in vitro comparison of tacrine and 7-methoxytacrine" . "0172-780X" . "382617" . "4"^^ . "New performance of biosensor technology for Alzheimer\u00B4s disease drugs: in vitro comparison of tacrine and 7-methoxytacrine"@en . . . "Kassa, Ji\u0159\u00ED" . . "Pohanka, Miroslav" . . . . "SE - \u0160v\u00E9dsk\u00E9 kr\u00E1lovstv\u00ED" . . . . . "[51E7B5D3B1D7]" . "Ku\u010Da, Kamil" . "000261553200030" . . . "5" . "Two drugs were tested using electrochemical biosensor with immobilized acetylcholinesterase (AChE). The first was commercialized drug tacrine (known also as Cognex) used for treatment of cognitive manifestation of Alzheimer\u00B4s disease (AD). The second one was its 7-methoxy derivate (7-MEOTA) that has not been marketed. We determined the IC50 (6.67+/-0.92)x10-7 M for tacrine and (1.66+/-1.43)x10-9 M for 7-MEOTA. In this in vitro study, 7-MEOTA acts as stronger inhibitor of AChE and in this way could be more favorable for treatment of cognitive manifestation of AD. Our study shows that biosensor technology could be used as a quick and cheap tool for testing of promising AChE inhibitors (AD drug candidates)."@en .