"ELISA IgG concentrations and opsonophagocytic activity following pneumococcal protein D conjugate vaccination and relationship to efficacy against acute otitis media" . "11" . "1962-1968" . "[65BF86D47957]" . "ELISA IgG koncentrace a obsonofagotytick\u00E1 aktivita po vakcinaci pneumokokovouvakcinou konjugovanou na protein D a vztah k \u00FA\u010Dinnosti proti akutn\u00EDmu z\u00E1n\u011Btu st\u0159edn\u00EDho ucha"@cs . "We explored the relationship between efficacy against acute otitis media (AOM) and both ELISA anti-polysaccharide IgG geometric mean concentrations (GMCs) and opsonophagocytic (OPA) geometric mean titres (GMTs) following primary and booster vaccination with pneumococcal protein D (Haemophilus influenzae-derived) conjugate vaccine. It was possible to distinguish between the OPA GMTs of low and high efficacy serotypes, however no such distinction was evident for ELISA GMCs. Also, there was a trend towards lower ELISA and OPA serotype-specific responses in subjects who developed AOM compared to controls. We conclude that serotype-specific OPA GMTs are an important endpoint to consider for evaluation of pneumococcal conjugate vaccines with respect to the protective efficacy against AOM (Study ID: 347414/NCT00119743)." . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "ELISA IgG koncentrace a obsonofagotytick\u00E1 aktivita po vakcinaci pneumokokovou vakcinou konjugovanou na protein D a vztah k \u00FA\u010Dinnosti proti akutn\u00EDmu z\u00E1n\u011Btu st\u0159edn\u00EDho ucha"@cs . "7"^^ . . "Z(MO0FVZ0000502)" . "0264-410X" . "ELISA IgG concentrations and opsonophagocytic activity following pneumococcal protein D conjugate vaccination and relationship to efficacy against acute otitis media"@en . "ELISA IgG koncentrace a obsonofagotytick\u00E1 aktivita po vakcinaci pneumokokovou vakcinou konjugovanou na protein D a vztah k \u00FA\u010Dinnosti proti akutn\u00EDmu z\u00E1n\u011Btu st\u0159edn\u00EDho ucha"@cs . "Prymula, Roman" . . "G44" . . . . "25" . "419912" . "We explored the relationship between efficacy against acute otitis media (AOM) and both ELISA anti-polysaccharide IgG geometric mean concentrations (GMCs) and opsonophagocytic (OPA) geometric mean titres (GMTs) following primary and booster vaccination with pneumococcal protein D (Haemophilus influenzae-derived) conjugate vaccine. It was possible to distinguish between the OPA GMTs of low and high efficacy serotypes, however no such distinction was evident for ELISA GMCs. Also, there was a trend towards lower ELISA and OPA serotype-specific responses in subjects who developed AOM compared to controls. We conclude that serotype-specific OPA GMTs are an important endpoint to consider for evaluation of pneumococcal conjugate vaccines with respect to the protective efficacy against AOM (Study ID: 347414/NCT00119743)."@en . "Poolman, Jan" . "Henckaerts, Isabelle" . "1"^^ . "RIV/60162694:G44__/07:00001873!RIV08-MO0-G44_____" . "4"^^ . . "ELISA IgG concentrations and opsonophagocytic activity following pneumococcal protein D conjugate vaccination and relationship to efficacy against acute otitis media" . . . "Pneumococcal protein D conjugate vaccine; ELISA IgG and opsonophagocytic antibodies; Acute otitis media"@en . "ELISA IgG concentrations and opsonophagocytic activity following pneumococcal protein D conjugate vaccination and relationship to efficacy against acute otitis media"@en . . . "RIV/60162694:G44__/07:00001873" . . "Vaccine" . "Schuerman, Lode" . . . . .