. "Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications" . . . . "G44" . . . . . . "Strukturn\u00ED faktory ovliv\u0148uj\u00EDc\u00ED schopnost v sou\u010Dasnosti u\u017E\u00EDvan\u00FDch reaktiv\u00E1tor\u016F AChE l\u00E9\u010Dit cyklosarinov\u00E9 intoxikace."@cs . "Current Pharmaceutical Design" . . . "Cyclosarin is one member of nerve agents\u00B4 family. Recent treatment of intoxications by organophosphorus compounds, such as nerve agents or pesticides, consists of rapid administration of anticholinergics and AChE reactivators. Owing to the threat of terroristic use of these compounds during last years, improvement of antidotal therapy still continues. As the part of the development of new antidotes, many new AChE reactivators were synthesized and currently some of them are under consideration for introducing them to the medical praxis. Their biological activity depends, as in the case of other drugs, on their chemical structure, which affects their pharmacokinetic (adsorption, distribution, metabolism and excretion) and pharmacodynamics. In this review, we would like to discuss relationship between structure of currently available AChE reactivators and their potency to reactivate cyclosarin-inhibited AChE. All outlined structural factors presented in this work should be helpful for the design of new"@en . "Ku\u010Da, Kamil" . "Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications"@en . "P(GP305/07/P162)" . "Cyclosarin is one member of nerve agents\u00B4 family. Recent treatment of intoxications by organophosphorus compounds, such as nerve agents or pesticides, consists of rapid administration of anticholinergics and AChE reactivators. Owing to the threat of terroristic use of these compounds during last years, improvement of antidotal therapy still continues. As the part of the development of new antidotes, many new AChE reactivators were synthesized and currently some of them are under consideration for introducing them to the medical praxis. Their biological activity depends, as in the case of other drugs, on their chemical structure, which affects their pharmacokinetic (adsorption, distribution, metabolism and excretion) and pharmacodynamics. In this review, we would like to discuss relationship between structure of currently available AChE reactivators and their potency to reactivate cyclosarin-inhibited AChE. All outlined structural factors presented in this work should be helpful for the design of new" . "[944234A38792]" . "452860" . . "Acetylcholinesterase; nerve agent; antidotes; cyclosarin; reactivators; oxime"@en . "Strukturn\u00ED faktory ovliv\u0148uj\u00EDc\u00ED schopnost v sou\u010Dasnosti u\u017E\u00EDvan\u00FDch reaktiv\u00E1tor\u016F AChE l\u00E9\u010Dit cyklosarinov\u00E9 intoxikace"@cs . . "AE - St\u00E1t Spojen\u00E9 arabsk\u00E9 emir\u00E1ty" . . "Bajgar, Ji\u0159\u00ED" . . "Jun, Daniel" . . . "3"^^ . . "RIV/60162694:G44__/07:00001809" . "1381-6128" . "8"^^ . "33" . . "RIV/60162694:G44__/07:00001809!RIV09-GA0-G44_____" . "Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications"@en . "3"^^ . "Strukturn\u00ED faktory ovliv\u0148uj\u00EDc\u00ED schopnost v sou\u010Dasnosti u\u017E\u00EDvan\u00FDch reaktiv\u00E1tor\u016F AChE l\u00E9\u010Dit cyklosarinov\u00E9 intoxikace"@cs . "13" . "Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications" . .