"425862" . "5"^^ . "Oximes are cholinesterase reactivators of use in poisoning with organophosphorus ester enzyme inhibitors. Pralidoxime (PRX) is the oxime used in the United States. Clinical experience with pralidoxime (and other oximes) is disappointing and the routine use has been questioned. Furthermore oximes are not equally effective against all existent enzyme inhibitors. There is a clear demand for 'broad spectrum' cholinesterase reactivators with a higher efficacy than those clinically available. To meet this need over the years new reactivators of cholinesterase of potential clinical utility have been developed. The purpose of the study was to quantify 'in vitro' the extent of protection conferred by available (pralidoxime and methoxime) and experimental (K-27, K-33 and K-48) oximes, using methyl-paraoxon (methyl-POX) as an esterase inhibitor and to compare the results with those previously obtained using paraoxon (POX) as an inhibitor. Red blood cell (RBC) acetylcholinesterase (AChE) act"@en . . . "Z(MO0FVZ0000604)" . "RIV/60162694:G44__/07:00001806" . "Nurulain, S. M." . "In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon" . "8"^^ . . "In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon" . . . "Journal of Applied Toxicology" . . "2"^^ . "[E5E4F8427560]" . . "In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon"@en . "In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon"@en . "168-175" . "RIV/60162694:G44__/07:00001806!RIV08-MO0-G44_____" . "Ku\u010Da, Kamil" . . "Kassa, Ji\u0159\u00ED" . . . "Arafat, K." . . . . "cholinesterase; organophosphate; methyl-paraoxon; oxime; pralidoxime; methoxime; K-oxime"@en . . "In vitro oximov\u00E1 reaktivace AChE \u010Derben\u00FDch krvinek inhibovan\u00E9 methyl-paraoxonem"@cs . . "0260-437X" . "2" . . . . "In vitro oximov\u00E1 reaktivace AChE \u010Derben\u00FDch krvinek inhibovan\u00E9 methyl-paraoxonem"@cs . "Oximes are cholinesterase reactivators of use in poisoning with organophosphorus ester enzyme inhibitors. Pralidoxime (PRX) is the oxime used in the United States. Clinical experience with pralidoxime (and other oximes) is disappointing and the routine use has been questioned. Furthermore oximes are not equally effective against all existent enzyme inhibitors. There is a clear demand for 'broad spectrum' cholinesterase reactivators with a higher efficacy than those clinically available. To meet this need over the years new reactivators of cholinesterase of potential clinical utility have been developed. The purpose of the study was to quantify 'in vitro' the extent of protection conferred by available (pralidoxime and methoxime) and experimental (K-27, K-33 and K-48) oximes, using methyl-paraoxon (methyl-POX) as an esterase inhibitor and to compare the results with those previously obtained using paraoxon (POX) as an inhibitor. Red blood cell (RBC) acetylcholinesterase (AChE) act" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Byly testov\u00E1ny reaktiv\u00E1tory K027, K048 a K033 jako\u017Eto antidota p\u0159i otrav\u00E1ch methyl-paraoxonem in vitro."@cs . "27" . . . "G44" . "Petroianu, G. A." .