"2"^^ . . "RIV/60162694:G44__/06:00001496" . . . . "Oximes K033 [1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide] and K048 [1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide] were tested as pretreatment drugs in tabun-poisoned mice followed by treatment with atropine plus K033, K048, K027 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide], TMB-4 [1,3-bis(4-hydroxyiminomethylpyridinium) propane dibromide] and HI-6 [(1-(2-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane dichloride)]. Oxime doses of 25% or 5% of its LD(50) were used for pretreatment 15min before tabun-poisoning and for treatment 1min after tabun administration to mice. The best therapeutic effect was obtained when oxime K048 (25% of its LD(50)) was used in both pretreatment and treatment with atropine. This regiment insured survival of all tested animals after the application of 10 LD(50) of tabun. In addition, since butyrylcholinesterase (BChE; EC 3.1.1.8) is considered an endogenous bioscavenger of an"@en . . "Luci\u0107-Vrdoljak, A." . "\u010Cali\u0107, M." . . . "Oximes K033 [1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide] and K048 [1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide] were tested as pretreatment drugs in tabun-poisoned mice followed by treatment with atropine plus K033, K048, K027 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide], TMB-4 [1,3-bis(4-hydroxyiminomethylpyridinium) propane dibromide] and HI-6 [(1-(2-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane dichloride)]. Oxime doses of 25% or 5% of its LD(50) were used for pretreatment 15min before tabun-poisoning and for treatment 1min after tabun administration to mice. The best therapeutic effect was obtained when oxime K048 (25% of its LD(50)) was used in both pretreatment and treatment with atropine. This regiment insured survival of all tested animals after the application of 10 LD(50) of tabun. In addition, since butyrylcholinesterase (BChE; EC 3.1.1.8) is considered an endogenous bioscavenger of an" . "Berend, S." . . . . "acetylcholinesterase; antidote; bioscavenger; butyrylcholinesterase; nerve agents; oxime; pretreatment; tabun"@en . "Kovarik, Z." . "000242135900005" . "Jun, Daniel" . "Ku\u010Da, Kamil" . . "0300-483X" . "Toxicology" . "Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning"@en . . "228" . . "Radi\u0107, B." . "10"^^ . "N" . "G44" . "Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning" . "Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning"@en . . "1" . "7"^^ . . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning" . . "RIV/60162694:G44__/06:00001496!RIV10-MO0-G44_____" . "[02D6507BBE39]" . . "494338" .