"Potency of new structurally different oximes to reactivate cyclosarin inhibited-human brain acetylcholinesterases"@en . "663-666" . "Antidotes currently used in the case of organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes. Owing to the wide-spread of these compounds worldwide, development of antidotes for the case of the first aid is needed. To select the most promising AChE reactivators is very time consuming process, which is necessary before approval of these compounds to be used as human antidotes. Because of ethical reasons, many developing experiments have been conducted on laboratory animals. However, these results could not be often transferred directly to human. Due to this fact, in our work, we have tested five newly developed AChE reactivators # K027, K033, K048, K074 and K075, which achieved promising reactivation activity on rodents, as reactivators of human brain cholinesterases. For this purpose, cyclosarin was used as member of the nerve agent family. H-oxime HI-6 and pralidoxime were used as"@en . "RIV/60162694:G44__/06:00001490" . "4"^^ . "Schopnost nov\u00FDch strukturn\u011B odli\u0161n\u00FDch oxim\u016F reaktivovat cyclosarinem inhibovanou acetylcholinester\u00E1zu z lidsk\u00E9ho mozku"@cs . "Schopnost nov\u00FDch strukturn\u011B odli\u0161n\u00FDch oxim\u016F reaktivovat cyclosarinem inhibovanou acetylcholinester\u00E1zu z lidsk\u00E9ho mozku"@cs . . "Potency of new structurally different oximes to reactivate cyclosarin inhibited-human brain acetylcholinesterases" . "Antidotes currently used in the case of organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes. Owing to the wide-spread of these compounds worldwide, development of antidotes for the case of the first aid is needed. To select the most promising AChE reactivators is very time consuming process, which is necessary before approval of these compounds to be used as human antidotes. Because of ethical reasons, many developing experiments have been conducted on laboratory animals. However, these results could not be often transferred directly to human. Due to this fact, in our work, we have tested five newly developed AChE reactivators # K027, K033, K048, K074 and K075, which achieved promising reactivation activity on rodents, as reactivators of human brain cholinesterases. For this purpose, cyclosarin was used as member of the nerve agent family. H-oxime HI-6 and pralidoxime were used as" . "1475-6366" . . "Jun, Daniel" . . . "Potency of new structurally different oximes to reactivate cyclosarin inhibited-human brain acetylcholinesterases"@en . "cholinesterase; reactivator; cyclosarin; human brain; nerve agent"@en . . . . "Z(MO0FVZ0000501)" . . . "5"^^ . . "Potency of new structurally different oximes to reactivate cyclosarin inhibited-human brain acetylcholinesterases" . . "5"^^ . . "Hrabinov\u00E1, Martina" . . "Schopnost nov\u011B vyvinu\u00FDch reaktiv\u00E1tor\u016F acetylcholinester\u00E1zy (K027, K033, K048, K074 a K075) byla testov\u00E1na na cholinester\u00E1z\u00E1ch lidsk\u00E9ho mozku inhibovan\u00FDch nervov\u011B paralytickou l\u00E1tkou cyklosarin."@cs . . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Journal of Enzyme Inhibition and Medicinal Chemistry" . "6" . "Ku\u010Da, Kamil" . "Bajgar, Ji\u0159\u00ED" . . . "Cabal, Ji\u0159\u00ED" . . "RIV/60162694:G44__/06:00001490!RIV07-MO0-G44_____" . . "[6A0CC4783224]" . . "493375" . "G44" .