"Quantification of efficiency of monopyridinium isomers and homologs derived from clinical used pralidoxim within reactivation of acetylcholinesterase inhibited with organophosphorus nerve agents. This work uses the colorimetric biosensor called Detehit \u2013 cotton cloth with immobilized enzyme acetylcholinesterase. Biosensor is based on the modificated Ellman method. The highest reactivation was observed with sarin-inhibited acetylcholinesterase. Substantially lower reactivation was found with the cyclosarin-inhibited enzyme whereas AChE, inhibited by soman could not be effectively reactivated under the given conditions enzyme inhibition for 2 minutes and subsequent treatment with the reactivator for 15 minutes. Our work gives comparison of efficiency of reactivators in dependence on the lenght of alkylene chain and position of aldoxime functional group. Evaluation of effectivity of aldoxime reactivators is provided by simple means."@en . . . . . . . "Quantification of efficiency of monopyridinium isomers and homologs derived from clinical used pralidoxim within reactivation of acetylcholinesterase inhibited with organophosphorus nerve agents. This work uses the colorimetric biosensor called Detehit \u2013 cotton cloth with immobilized enzyme acetylcholinesterase. Biosensor is based on the modificated Ellman method. The highest reactivation was observed with sarin-inhibited acetylcholinesterase. Substantially lower reactivation was found with the cyclosarin-inhibited enzyme whereas AChE, inhibited by soman could not be effectively reactivated under the given conditions enzyme inhibition for 2 minutes and subsequent treatment with the reactivator for 15 minutes. Our work gives comparison of efficiency of reactivators in dependence on the lenght of alkylene chain and position of aldoxime functional group. Evaluation of effectivity of aldoxime reactivators is provided by simple means." . . "1" . "312479" . "Neuroendocrinology Letters" . "Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman" . . . . . "acetylcholinesterase; acetylcholinesterase reactivators; chemical warfare agents; nerve agent; pralidoxime; sarin; cyclosarin; soman"@en . "3"^^ . "Z(MO0UOPZHN0401)" . "000261553200013" . "Hal\u00E1mek, Emil" . . "0172-780X" . "G38" . "3"^^ . . . . "RIV/60162694:G38__/09:#0000142!RIV10-MO0-G38_____" . . "4"^^ . . "30" . "Kobliha, ZBYN\u011AK" . . "Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman"@en . . "Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman" . . "Hoskovcov\u00E1, Monika" . "[F318FC0A5EA9]" . . "SE - \u0160v\u00E9dsk\u00E9 kr\u00E1lovstv\u00ED" . . "Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman"@en . "RIV/60162694:G38__/09:#0000142" .