"Cyclohexyl methylphosphonofluoridate (cyclosarin, cyclosin, GF) is a highly toxic organophosphate, which was resistant to conventional oxime therapy. To give more insight into the reactivation kinetics, rat brain acetylcholinesterase (AChE) was inhibited in vitro by cyclosarin (pH 8.0, 25 \u00B0C) and reactivated with 22 different pyridinium-oximes. Only three compounds were shown to be superior to the other oximes: 4-carbamoyl-4\u00B4-[(hydroxyimino)methyl]-1,1\u00B4-(oxydimethylene)dipyridin-1-ium dichloride (HS-6), 4\u00B4-carbamoyl-2-[(hydroxyimino)methyl]-1,1\u00B4-(oxydimethylene)dipyridin-1-ium dichloride (HI-6), and 4\u00B4-carbamoyl-2-[(hydroxyimino)methyl]-1,1\u00B4-(but-2-ene-1,4-diyl)dipyridin-1-ium dichloride (BI-6)." . "acetylcholinesterase;oxime;reactivation;cyclosarin;in vitro"@en . "Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes"@en . "Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes"@en . "RIV/60162694:G38__/04:00001080" . "Reaktivace cyklosarinem inhibovan\u00E9 acetylcholinester\u00E1zy pyridiniov\u00FDmi oximy"@cs . . . "Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes" . . "Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes" . "P(ONVLAJEP20031)" . "Pato\u010Dka, Ji\u0159\u00ED" . "[C4B9E30C731A]" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "Journal of Enzyme Inhibition and Medicinal Chemistry" . "2"^^ . "1" . "RIV/60162694:G38__/04:00001080!RIV/2005/MO0/G38005/N" . . . "5"^^ . "Cyclohexyl methylphosphonofluoridate (cyclosarin, cyclosin, GF) is a highly toxic organophosphate, which was resistant to conventional oxime therapy. To give more insight into the reactivation kinetics, rat brain acetylcholinesterase (AChE) was inhibited in vitro by cyclosarin (pH 8.0, 25 \u00B0C) and reactivated with 22 different pyridinium-oximes. Only three compounds were shown to be superior to the other oximes: 4-carbamoyl-4\u00B4-[(hydroxyimino)methyl]-1,1\u00B4-(oxydimethylene)dipyridin-1-ium dichloride (HS-6), 4\u00B4-carbamoyl-2-[(hydroxyimino)methyl]-1,1\u00B4-(oxydimethylene)dipyridin-1-ium dichloride (HI-6), and 4\u00B4-carbamoyl-2-[(hydroxyimino)methyl]-1,1\u00B4-(but-2-ene-1,4-diyl)dipyridin-1-ium dichloride (BI-6)."@en . . "583624" . . "2"^^ . "G38" . . . "39-43" . . "Reaktivace cyklosarinem inhibovan\u00E9 acetylcholinester\u00E1zy pyridiniov\u00FDmi oximy"@cs . "Ku\u010Da, Kamil" . . . "8755-5093" . "Reaktivace cyklosarinem inhibovan\u00E9 acetylcholinester\u00E1zy pyridiniov\u00FDmi oximy"@cs . . . . . . "19" .