. "CZ - \u010Cesk\u00E1 republika" . "1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents"@en . . "47" . . . "The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX were tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator - pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10-4 M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10-1 M [for cyclosarin] and 10-3 M [for VX] but these concentrations are not available for the use in vivo." . "Dohnal, Vlastimil" . "3" . . "Ku\u010Da, Kamil" . . "167-169" . . . . . . "1,3-bis(2-hydroxyiminomethylpyridinium) propan jako potenci\u00E1ln\u00ED reaktiv\u00E1tor acetylcholinester\u00E1zy inhibovan\u00E9 nervov\u011B paralytick\u00FDmi l\u00E1tkami"@cs . "G38" . "RIV/60162694:G38__/04:00001077" . . . . "[D87CEB80573F]" . . "1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents"@en . "The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX were tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator - pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10-4 M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10-1 M [for cyclosarin] and 10-3 M [for VX] but these concentrations are not available for the use in vivo."@en . "1211-4286" . "596503" . "2"^^ . "RIV/60162694:G38__/04:00001077!RIV/2005/MO0/G38005/N" . . . . . . . "1"^^ . "acetylcholinesterase;reactivation;inhibition;oximes;reactivator;pralidoxime;cyclosarin;VX;in vitro;K005;nerve agents;organophosphates"@en . "1,3-bis(2-hydroxyiminomethylpyridinium) propan jako potenci\u00E1ln\u00ED reaktiv\u00E1tor acetylcholinester\u00E1zy inhibovan\u00E9 nervov\u011B paralytick\u00FDmi l\u00E1tkami"@cs . "Acta Medica (Hradec Kr\u00E1lov\u00E9)" . "1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents" . "P(ONVLAJEP20031)" . "1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents" . "3"^^ . . . . "1,3-bis(2-hydroxyiminomethylpyridinium) propan jako potenci\u00E1ln\u00ED reaktiv\u00E1tor acetylcholinester\u00E1zy inhibovan\u00E9 nervov\u011B paralytick\u00FDmi l\u00E1tkami"@cs .