"Byl zaveden test na kapacitu reparace DNA. Kapacita reparace DNA ur\u010Duje citlivost jedince k \u00FA\u010Dink\u016Fm z\u00E1\u0159en\u00ED a chemick\u00FDch mutagen\u016F - karcinogen\u016F a vykazuje u lid\u00ED interindividu\u00E1ln\u00ED variabilitu. Pom\u011Brn\u011B dobr\u00E1 reproducibilita n\u00E1mi pou\u017E\u00EDvan\u00E9ho testu d\u00E1v\u00E1mo\u017Enost jeho vyu\u017Eit\u00ED pro testov\u00E1n\u00ED kapacity opravy po\u0161kozen\u00ED DNA indukovan\u00E9ho ionizuj\u00EDc\u00EDm z\u00E1\u0159en\u00EDm, a to jak u exp. zv\u00ED\u0159at tak i u lid\u00ED. Sarin ani soman reparaci DNA neinhibovaly, ur\u010Dit\u00E9 statisticky nev\u00FDznamn\u00E9 zpomalen\u00ED reparace bylo zji\u0161t\u011Bno u lymfocy t\u016F izolovan\u00FDch z my\u0161\u00ED po aplikaci HI-6. Soman i oxim HI-6 vykazoval schopnost indukce oxidaivn\u00EDho po\u0161kozen\u00ED DNA, sarin takov\u00E9to po\u0161kozen\u00ED neindukoval. Soman zvy\u0161uje zlom\u016F DNA indukovan\u00FDch AFB1, a lze se tedy domn\u00EDvat, \u017Ee je schopen potencovat \u00FA\u010Dinky karcinogen\u016F z prost\u0159ed\u00ED. Na druh\u00E9 stran\u011B oxim HI-6 inhiboval indukci SSB po aplikaci AFB1a tak sni\u017Eoval jeho mutagenn\u00ED \u00FA\u010Dinky. HI-6 inhiboval mutagenn\u00ED \u00FA\u010Dinky alkyla\u010Dn\u00EDch l\u00E1tek methylnitrosoguanidinu (MNNG), a methylnitrosomo\u010Doviny (MNU). Inhiboval induk" . . "35"^^ . . . "RIV/60162694:G16__/02:00000858" . "\u0160t\u011Btina, Rudolf" . . . . "Ov\u011B\u0159en\u00ED genotoxicity sarinu, somanu a oximu HI-6, a prostudov\u00E1n\u00ED jejich vlivu na \u00FA\u010Dinek mutagenn\u00EDch a karcinogenn\u00EDch l\u00E1tek (genotoxicita) - MUTAGEN"@cs . . "Ov\u011B\u0159en\u00ED genotoxicity sarinu, somanu a oximu HI-6, a prostudov\u00E1n\u00ED jejich vlivu na \u00FA\u010Dinek mutagenn\u00EDch a karcinogenn\u00EDch l\u00E1tek (genotoxicita) - MUTAGEN"@cs . . "G44" . . "1"^^ . "Ov\u011B\u0159en\u00ED genotoxicity sarinu, somanu a oximu HI-6, a prostudov\u00E1n\u00ED jejich vlivu na \u00FA\u010Dinek mutagenn\u00EDch a karcinogenn\u00EDch l\u00E1tek (genotoxicita) - MUTAGEN" . "657574" . "Ov\u011B\u0159en\u00ED genotoxicity sarinu, somanu a oximu HI-6, a prostudov\u00E1n\u00ED jejich vlivu na \u00FA\u010Dinek mutagenn\u00EDch a karcinogenn\u00EDch l\u00E1tek (genotoxicita) - MUTAGEN" . "1"^^ . "genotoxicity; sarin; soman; HI-6 oxime; low doses"@en . "VLA JEP" . . "We have worked out a method for the testing of DNA reapir capacity. The DNA repair capacity showes an interindividual variability and it determines the idividual sensitivity to effects of radiartion and of chemical mutagens-carcinogens. The relatively good reproducibility of our test gives a chance for using it for the testing of the capacity to repair the DNA damage caused by the ionising radiation both in humans and in experimental animals. Neither the sarin nor the soman inhibited the DNA repair capacity. On the other hand HI-6 oxime caused a mild decrease of the DNA repair rate in lymppcytes isolated from treated mice. In contrast to sarin, both somand and HI-6 induced induced a mild oxidative DNA damage. Soman potentiated the induction of DNA breaks caused by aflatoxin B1 and so it could have a capacity to increase the effect of environmental mutagens. In contrast to this finding, HI-6 oxime inhibited he induction of DNA breaks by aflatoxin B1 and so it dereased its mutagenic effec"@en . . "RIV/60162694:G16__/02:00000858!RIV/2003/MO0/G16003/N" . "[0C713A326F9F]" . "The study of genotoxicity of sarin, soman and HI-6 oxime, and their influence on the effect of mutagenic and carcinogenic compounds"@en . . "Hradec Kr\u00E1lov\u00E9" . "Neuveden" . "The study of genotoxicity of sarin, soman and HI-6 oxime, and their influence on the effect of mutagenic and carcinogenic compounds"@en . . . . . "P(MO66021299108)" . .