"Characterization of Hepatocellular Carcinoma Related Genes and Metabolites in Human Nonalcoholic Fatty Liver Disease"@en . . "The worldwide prevalences of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are estimated to range from 30 to 40 % and 5-17 %, respectively. Hepatocellular carcinoma (HCC) is primarily caused by hepatitis B infection, but retrospective data suggest that 4-29 % of NASH cases will progress to HCC. Currently the connection between NASH and HCC is unclear. The purpose of this study was to identify changes in expression of HCC-related genes and metabolite profiles in NAFLD progression. Transcriptomic and metabolomic datasets from human liver tissue representing NAFLD progression (normal, steatosis, NASH) were utilized and compared to published data for HCC. Genes involved in Wnt signaling were downregulated in NASH but have been reported to be upregulated in HCC. Extracellular matrix/angiogenesis genes were upregulated in NASH, similar to reports in HCC." . "Characterization of Hepatocellular Carcinoma Related Genes and Metabolites in Human Nonalcoholic Fatty Liver Disease" . . "I, Z(AV0Z50510513)" . "Robertson, D." . "Clarke, D. J." . "59" . . . "0163-2116" . "[DC23F95A1E5F]" . "Severson, P. L." . "Futscher, B. W." . . "Shipkova, P." . "Aranibar, N." . "RIV/60077344:_____/14:00430509" . "10"^^ . "Cherrington, N. J." . . . "Lehman-McKeeman, L. D." . "Lake, A. D." . "RIV/60077344:_____/14:00430509!RIV15-AV0-60077344" . "NL - Nizozemsko" . . "nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; hepatocellular carcinoma; metabolomics"@en . "Nov\u00E1k, Petr" . "10.1007/s10620-013-2873-9" . "11"^^ . "The worldwide prevalences of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are estimated to range from 30 to 40 % and 5-17 %, respectively. Hepatocellular carcinoma (HCC) is primarily caused by hepatitis B infection, but retrospective data suggest that 4-29 % of NASH cases will progress to HCC. Currently the connection between NASH and HCC is unclear. The purpose of this study was to identify changes in expression of HCC-related genes and metabolite profiles in NAFLD progression. Transcriptomic and metabolomic datasets from human liver tissue representing NAFLD progression (normal, steatosis, NASH) were utilized and compared to published data for HCC. Genes involved in Wnt signaling were downregulated in NASH but have been reported to be upregulated in HCC. Extracellular matrix/angiogenesis genes were upregulated in NASH, similar to reports in HCC."@en . . "Reily, M. D." . . "6942" . . "000331651900020" . . . "Characterization of Hepatocellular Carcinoma Related Genes and Metabolites in Human Nonalcoholic Fatty Liver Disease"@en . . "Digestive Diseases and Sciences" . . . "1"^^ . "2" . "Characterization of Hepatocellular Carcinoma Related Genes and Metabolites in Human Nonalcoholic Fatty Liver Disease" . .