. "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Journal of Biological Rhythms" . "Britt, S. G." . "Rhodpsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster in independent of retinal phospholipase C-beta signaling" . "1" . "Sehadov\u00E1, Hana" . "1"^^ . . "165553" . "0748-7304" . "In Drosophila, the compound eye photoreceptors and the H-B eyelet, a specialized photoreceptive structure located between the retina and the optic lobes, contain Rhodopsin photopigments, which activate the canonical invertebrate phototransduction cascade after being excited by light. We show that 2 of the photopigments present in these photoreceptors, Rhodopsin 5 (Rh5) and Rhodopsin 6 (Rh6), contribute to light synchronization in a mutant (norpAP41) that disrupts canonical phototransduction due to the absence of Phospholipase C-\u03B2(PLC-\u03B2). We reveal that norpAP41 is a true loss-of-function allele, resulting in a truncated PLC-\u03B2protein that lacks the catalytic domain. Light reception mediated by Rh5 and Rh6 must therefore utilize either a different (nonretinal) PLC-\u03B2enzyme or alternative signaling mechanisms, at least in terms of clockrelevant photoreception."@en . "Rhodopsin 5; Rhodopsin 6; phospholipase"@en . "Chou, W.-H." . "Rhodpsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster in independent of retinal phospholipase C-beta signaling"@en . . . "Szular, J." . . . "7"^^ . . . "Rhodpsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster in independent of retinal phospholipase C-beta signaling"@en . . "I" . "RIV/60077344:_____/12:00390649" . "RIV/60077344:_____/12:00390649!RIV13-AV0-60077344" . . "Szabo, G." . "In Drosophila, the compound eye photoreceptors and the H-B eyelet, a specialized photoreceptive structure located between the retina and the optic lobes, contain Rhodopsin photopigments, which activate the canonical invertebrate phototransduction cascade after being excited by light. We show that 2 of the photopigments present in these photoreceptors, Rhodopsin 5 (Rh5) and Rhodopsin 6 (Rh6), contribute to light synchronization in a mutant (norpAP41) that disrupts canonical phototransduction due to the absence of Phospholipase C-\u03B2(PLC-\u03B2). We reveal that norpAP41 is a true loss-of-function allele, resulting in a truncated PLC-\u03B2protein that lacks the catalytic domain. Light reception mediated by Rh5 and Rh6 must therefore utilize either a different (nonretinal) PLC-\u03B2enzyme or alternative signaling mechanisms, at least in terms of clockrelevant photoreception." . . "000299848100003" . "Rhodpsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster in independent of retinal phospholipase C-beta signaling" . "[C366CBB5000A]" . "Gentile, C." . . "Stanewsky, R." . "12"^^ . . . "10.1177/0748730411431673" . "27" .