"Kopeck\u00FD, Jan" . "Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection"@en . "RIV/60077344:_____/12:00375992" . . "Type I interferons (IFN-a and IFN-beta) are crucial determinants of the host immune response and tick saliva modulates this response, thus facilitating the transmission of tickborne pathogens. The current study therefore examines the effect of Ixodes ricinus tick saliva on IFN-beta signalling in murine dendritic cells using lipopolysaccharide (LPS) and Borrelia afzelii spirochaetes as inducers. Our results show that Borrelia-induced activation of STAT-1 was suppressed by tick saliva. Our data indicate that similar to I. ricinus tick saliva may modulate the host immune response by attenuating the initial signal transduction pathway of type I IFN." . . . . "174427" . . "Borrelia; dendritic cells; interferon signalling; tick saliva"@en . . . "Type I interferons (IFN-a and IFN-beta) are crucial determinants of the host immune response and tick saliva modulates this response, thus facilitating the transmission of tickborne pathogens. The current study therefore examines the effect of Ixodes ricinus tick saliva on IFN-beta signalling in murine dendritic cells using lipopolysaccharide (LPS) and Borrelia afzelii spirochaetes as inducers. Our results show that Borrelia-induced activation of STAT-1 was suppressed by tick saliva. Our data indicate that similar to I. ricinus tick saliva may modulate the host immune response by attenuating the initial signal transduction pathway of type I IFN."@en . "2"^^ . . "I, P(LC06009)" . . "RIV/60077344:_____/12:00375992!RIV13-AV0-60077344" . . . "Lieskovsk\u00E1, Jaroslava" . "2"^^ . . . . "8"^^ . "1" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection" . "[37D82870C073]" . "000298594000005" . "34" . . "Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection" . "Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection"@en . "Parasite immunology" . "0141-9838" . . . "10.1111/j.1365-3024.2011.01345.x" . .