. "370;374" . . . "In positron emission tomography (PET) alpha-methyl amino acids have two potential applications: As analogues of neutransmitter precursors for the study of neurodegenerative diseases, and as non-metabolised analogues of proteinogenic amino acids for the study of amino acid uptake into normal and cancer cells. Clinical applications of such amino acids are strongly limited due to their poor availability. We carried out [C-11]methylation of metalocomplex synthons derived from protected DOPA or tyrosine. After 10min at 25 \u00BAC, a 9% radiochemical yield (decay-corrected) of a mixture of the diastereomeric alpha-[C-11]methylDOPA complexes or a 7% radiochemical yield of a mixture of the diastereomeric alpha-[C-11]methyltyrosine complexes was achieved. Optimisation of the procedure including hydrolysis of the complexes (hydrolytic deprotection of enantiomerically pure amino acids) and subsequent purification of the enantiomers of a-[11C]methyID0PA and alpha-[C-11]methyltyrosine is underway."@en . "[5211640C6556]" . . "5"^^ . "Stereoselectivn\u00ED radiosynt\u00E9za alfa-[C-11]methylsubstituovan\u00FDch aromatick\u00FDch alfa-amino acids \u2013 stimul k synt\u00E9ze kvartern\u00EDho asymetrick\u00E9ho centra ve velmi kr\u00E1tk\u00E9 dob\u011B"@cs . . . "Towards stereoselective radiosynthesis of alpha-[C-11]methylsubstituted aromatic alpha-amino acids - a challenge of creation of quaternary asymmetric centre in a very short time"@en . "Kru\u017Ebersk\u00E1, Pavla" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "5-6" . "6"^^ . . . . . "V pozitronov\u00E9 emisn\u00ED tomografii (PET) alfa-amino kyseliny maj\u00ED dv\u011B aplikace: jako analogy neurotransmiterov\u00FDch prekurzor\u016F p\u0159i studiu neurodegenerativn\u00EDch onemocn\u011Bn\u00ED a jako nemetabolizovan\u00E9 analogy proteinotvorn\u00FDch aminokyselin p\u0159i studiu rakovinov\u00FDch bun\u011Bk. Klinick\u00E9 aplikace modifikovan\u00FDch aminokyselin jsou omezeny jejich nedostupnost\u00ED. V pr\u00E1cie zkoum\u00E1na [C-11] methylace metalokomplexn\u00EDch synthon\u016F DOPA a tyrosinu. P\u0159i 25\u00BAC po 10 min. byly z\u00EDsk\u00E1ny s 9% v\u00FDt\u011B\u017Ekem diastereomern\u00ED komplexy sm\u011Bsi alfa-[C-11] methylDOPA a se 7% v\u00FDt\u011B\u017Ekem sm\u011Bs alpha-[C-11]methyltyrosinov\u00E9ho komplexu. Optimalizace postupu v\u010Detn\u011B hydrol\u00FDzy komplex\u016F a \u010Di\u0161t\u011Bn\u00ED enantiomer\u016F alfa-[11C]methyID0PA and alfa-[C-11]methyltyrosinu jsou ve v\u00FDvoji."@cs . "N\u00E1dvorn\u00EDk, M." . "RIV/60077344:_____/07:00094858" . "Ly\u010Dka, A." . "Towards stereoselective radiosynthesis of alpha-[C-11]methylsubstituted aromatic alpha-amino acids - a challenge of creation of quaternary asymmetric centre in a very short time"@en . "Towards stereoselective radiosynthesis of alpha-[C-11]methylsubstituted aromatic alpha-amino acids - a challenge of creation of quaternary asymmetric centre in a very short time" . "S, Z(AV0Z50070508), Z(MSM6007665808)" . . . . "asymmetric synthesis; alfa-methyl amino acids; carbon-11"@en . "Lehel, S." . "Stereoselectivn\u00ED radiosynt\u00E9za alfa-[C-11]methylsubstituovan\u00FDch aromatick\u00FDch alfa-amino acids \u2013 stimul k synt\u00E9ze kvartern\u00EDho asymetrick\u00E9ho centra ve velmi kr\u00E1tk\u00E9 dob\u011B"@cs . "1"^^ . . "0362-4803" . "Towards stereoselective radiosynthesis of alpha-[C-11]methylsubstituted aromatic alpha-amino acids - a challenge of creation of quaternary asymmetric centre in a very short time" . "Popkov, A." . "455408" . . . "In positron emission tomography (PET) alpha-methyl amino acids have two potential applications: As analogues of neutransmitter precursors for the study of neurodegenerative diseases, and as non-metabolised analogues of proteinogenic amino acids for the study of amino acid uptake into normal and cancer cells. Clinical applications of such amino acids are strongly limited due to their poor availability. We carried out [C-11]methylation of metalocomplex synthons derived from protected DOPA or tyrosine. After 10min at 25 \u00BAC, a 9% radiochemical yield (decay-corrected) of a mixture of the diastereomeric alpha-[C-11]methylDOPA complexes or a 7% radiochemical yield of a mixture of the diastereomeric alpha-[C-11]methyltyrosine complexes was achieved. Optimisation of the procedure including hydrolysis of the complexes (hydrolytic deprotection of enantiomerically pure amino acids) and subsequent purification of the enantiomers of a-[11C]methyID0PA and alpha-[C-11]methyltyrosine is underway." . "Journal of Labelled Compounds and Radiopharmaceuticals" . "50" . "Gillings, N." . "RIV/60077344:_____/07:00094858!RIV08-AV0-60077344" .