"RIV/60077344:_____/06:00048903!RIV07-AV0-60077344" . . . . "Vliv extraktu slinn\u00FDch \u017El\u00E1z kl\u00ED\u0161t\u011Bte Ixodes ricinus na in vivo proliferaci spiroch\u00E9ty Borrelia burgdorferi sensu stricto"@cs . "0015-5683" . "473191" . "53" . "[757CD9F0CD51]" . . "Effect of salivary gland extract from Ixodes ricinus ticks on the proliferation of Borrelia burgdorferi sensu stricto in vivo"@en . . . "2" . . "3"^^ . "Effect of salivary gland extract from Ixodes ricinus ticks on the proliferation of Borrelia burgdorferi sensu stricto in vivo" . . . "Effect of salivary gland extract from Ixodes ricinus ticks on the proliferation of Borrelia burgdorferi sensu stricto in vivo" . "Effect of salivary gland extract from Ixodes ricinus ticks on the proliferation of Borrelia burgdorferi sensu stricto in vivo"@en . . "RIV/60077344:_____/06:00048903" . "3"^^ . . . . "Borrelia burgdorferi; Ixodes ricinus; saliva-activated transmission"@en . "Kopeck\u00FD, Jan" . "CZ - \u010Cesk\u00E1 republika" . "Hard-bodied tick Ixodes ricinus is an important vector of Lyme disease spirochete Borrelia burgdorferi sensu lato. Feeding of ixodid ticks extends over a number of days and it provides an opportunity for vector-host immune interaction. The interplay includes host immune defense against tick feeding as well as modulation of host immune response induced by tick feeding. Recently, increasing evidence supports the idea that tick-borne pathogens take advantage of immunomodulatory factors in tick saliva to facilitate their transmission. We have examined effect of salivary gland extract from I. ricinus on the spirochete proliferation during mouse infection, to test existence of saliva activated transmission (SAT). First direct evidence of B. burgdorferi SAT was demonstrated using real-time PCR on day 1 post infection, when a significant increase in spirochetes was found in mouse tissues, compared with control group." . "Oborn\u00EDk, Miroslav" . "P(GA524/05/0811), Z(AV0Z60220518), Z(MSM6007665801)" . "153;158" . "Vliv extraktu slinn\u00FDch \u017El\u00E1z kl\u00ED\u0161t\u011Bte Ixodes ricinus na in vivo proliferaci spiroch\u00E9ty Borrelia burgdorferi sensu stricto"@cs . . . . "Folia Parasitologica" . . "Mach\u00E1\u010Dkov\u00E1, Martina" . . . "6"^^ . . "Ixodes ricinus je d\u016Fle\u017Eit\u00FDm vektorem spiroch\u00E9ty Borrelia burgdorferi sensu lato, p\u016Fvodce Lymsk\u00E9 boreli\u00F3zy. Kl\u00ED\u0161\u0165ata \u010Deledi Ixodidae saj\u00ED na hostiteli po dobu n\u011Bkolika dn\u016F, co\u017E umo\u017E\u0148uje vznik vektor-hostitelsk\u00FDch interakc\u00ED. Toto vz\u00E1jemn\u00E9 p\u016Fsoben\u00ED zahrnuje imunitn\u00ED obranu hostitele a z\u00E1rove\u0148 modulaci hostitelsk\u00E9 odpov\u011Bdi vyvolan\u00E9 s\u00E1n\u00EDm kl\u00ED\u0161t\u011Bte. V sou\u010Dasn\u00E9 dob\u011B st\u00E1le v\u00EDce imunologick\u00FDch studi\u00ED podporuje hypot\u00E9zu, kter\u00E1 p\u0159edpokl\u00E1d\u00E1, \u017Ee patogeny p\u0159en\u00E1\u0161en\u00E9 kl\u00ED\u0161\u0165aty vyu\u017E\u00EDvaj\u00ED imunomodula\u010Dn\u00EDch molekul ve slin\u00E1ch kl\u00ED\u0161\u0165at k usnadn\u011Bn\u00ED vlastn\u00EDho p\u0159enosu do hostitele. Abychom zjistili, zda se slinami aktivovan\u00FD p\u0159enos (SAT) vyskytuje tak\u00E9 u spiroch\u00E9ty B. burgdorferi, sledovali jsme efekt extraktu ze slinn\u00FDch \u017El\u00E1z kl\u00ED\u0161t\u011Bte I. ricinus na mno\u017Een\u00ED boreli\u00ED v my\u0161\u00EDch tk\u00E1n\u00EDch. Prvn\u00ED den po infekci jsme pomoc\u00ED real-time PCR zaznamenali signifikantn\u00ED n\u00E1r\u016Fst spiroch\u00E9t v tk\u00E1n\u00EDch my\u0161\u00ED v porovn\u00E1n\u00ED s kontrolou. Tato data p\u0159edstavuj\u00ED prvn\u00ED p\u0159\u00EDm\u00FD d\u016Fkaz o existenci jevu SAT u B. burgdorferi sensu stricto."@cs . "Hard-bodied tick Ixodes ricinus is an important vector of Lyme disease spirochete Borrelia burgdorferi sensu lato. Feeding of ixodid ticks extends over a number of days and it provides an opportunity for vector-host immune interaction. The interplay includes host immune defense against tick feeding as well as modulation of host immune response induced by tick feeding. Recently, increasing evidence supports the idea that tick-borne pathogens take advantage of immunomodulatory factors in tick saliva to facilitate their transmission. We have examined effect of salivary gland extract from I. ricinus on the spirochete proliferation during mouse infection, to test existence of saliva activated transmission (SAT). First direct evidence of B. burgdorferi SAT was demonstrated using real-time PCR on day 1 post infection, when a significant increase in spirochetes was found in mouse tissues, compared with control group."@en .