"592396" . . . . . "Raman spectroscopy;fourier transform infrared spectroscopy;molecular modeling;orosomucoid;binding site;thermal dynamics"@en . "Vibra\u010Dn\u00ED spektroskopie a po\u010D\u00EDta\u010Dov\u00E9 modelov\u00E1n\u00ED proteinu: \u0159e\u0161en\u00ED struktury alpha-1-kysel\u00E9ho glykoproteinu"@cs . . "Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein"@en . . . "Spectroscopy - An International Journal" . . . "18" . "This work introduces a new approach connecting vibrational spectroscopy with homology and energetic molecular modeling of proteins. Combination of both methods can compensate their disadvantages and result in realistic three-dimensional protein models. The approach is most powerful for membrane proteins or glycoproteins with high carbohydrate content where X-ray or NMR analysis is not always successful. Nevertheless, it can also serve as a tool of preliminary analysis of any protein with unknown structure. Power of the approach is demonstrated on human alpha(1)-acid glycoprotein. Its predicted structure published in [V. Kopecky Jr. et al., Biochem. Biophys. Res. Commun. 300 (2003), 41-46] is discussed in detail with respect to the approach and its general employment." . "2" . . "Kopeck\u00FD, Vladim\u00EDr" . "Ettrich, Rudiger Horst" . "P(GP206/03/D082), P(LN00A141)" . "This work introduces a new approach connecting vibrational spectroscopy with homology and energetic molecular modeling of proteins. Combination of both methods can compensate their disadvantages and result in realistic three-dimensional protein models. The approach is most powerful for membrane proteins or glycoproteins with high carbohydrate content where X-ray or NMR analysis is not always successful. Nevertheless, it can also serve as a tool of preliminary analysis of any protein with unknown structure. Power of the approach is demonstrated on human alpha(1)-acid glycoprotein. Its predicted structure published in [V. Kopecky Jr. et al., Biochem. Biophys. Res. Commun. 300 (2003), 41-46] is discussed in detail with respect to the approach and its general employment."@en . . . "8"^^ . "12640" . "0712-4813" . "Nov\u00E9 metody pro rychl\u00FD odhad struktur proteinu byly vyv\u00EDjeny a vysv\u011Btleny na p\u0159\u00EDkladu lidsk\u00E9ho orosomukoidu"@cs . "Baumruk, Vladim\u00EDr" . . "[104EA04F8D6C]" . "Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein" . "Hofbauerov\u00E1, Kate\u0159ina" . "1"^^ . "Vibra\u010Dn\u00ED spektroskopie a po\u010D\u00EDta\u010Dov\u00E9 modelov\u00E1n\u00ED proteinu: \u0159e\u0161en\u00ED struktury alpha-1-kysel\u00E9ho glykoproteinu"@cs . "RIV/60076658:12640/04:00005714" . . "Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein"@en . . "4"^^ . "RIV/60076658:12640/04:00005714!RIV/2005/GA0/126405/N" . . "Vibrational spectroscopy and computer modeling of proteins: solving structure of alpha(1)-acid glycoprotein" . . . "NL - Nizozemsko" . "323-330" . .