. "[001196227637]" . "394513" . "Trattner, Sofia" . . "2"^^ . "000260526200003" . "Ruyter, B." . "Sesamin Increases Alpha-Linolenic Acid Conversion to Docosahexaenoic Acid in Atlantic Salmon (Salmo salar L.) Hepatocytes: Role of Altered Gene Expression"@en . . . "Z(MSM6007665809)" . "11" . . "Sezamin zv\u00FD\u0161uje konverzi alfa-linolenov\u00E9 kyseliny na kyselinu dokosahexaenovou v hepatocytech lososa obecn\u00E9ho (Salmo salar L.): Vliv na zm\u011Bnu genov\u00E9 exprese"@cs . "RIV/60076658:12610/08:00008924" . "In vitro kultivovan\u00E9 hepatocyty lososa obecn\u00E9ho (Salmo salar L.), byly inkubov\u00E1ny se sm\u011Bs\u00ED sezaminu a episezaminu pro zji\u0161t\u011Bn\u00ED mo\u017En\u00E9ho vlivu na metabolismus lipid\u016F. P\u0159id\u00E1ni sezaminu/episezaminu (0.05 mM, kone\u010Dn\u00E1 koncentrace) vedlo ke zv\u00FD\u0161en\u00ED elongace a desaturace 14C 18:3n-3 na dokosahexaenovou kyselinu (14C 22:6n-3, DHA, P0.01) a sn\u00ED\u017Een\u00ED genov\u00E9 exprese 6 a 5 desatur\u00E1sy v porovn\u00E1n\u00ED s kontrolou. Sezamin/episezamin zv\u00FD\u0161il kapacitu hepatocytov\u00E9 -oxidace 14C 18:3n-3 (P0.01) na 14C produkty, acet\u00E1t, mal\u00E1t and oxaloacet\u00E1t, p\u0159i\u010Dem\u017E byla zv\u00FD\u0161ena genov\u00E1 exprese karnitin palmitoyltransfer\u00E1sy I. Z\u00E1rove\u0148 byla zv\u00FD\u0161ena genov\u00E1 exprese klastru diferenciace 36 a exprese ?scavenger receptoru? typu B. Genov\u00E1 exprese PPAR a PPAR byla sn\u00ED\u017Eena. Mno\u017Estv\u00ED triacylglycerolu sekretovan\u00E9ho bu\u0148kami bylo sn\u00ED\u017Eeno v hepatocytech inkubovan\u00FDch za p\u0159\u00EDtomnosti sezaminu/episezaminu v porovn\u00E1n\u00ED s kontroln\u00EDmi bu\u0148kami. Touto studi\u00ED byl prok\u00E1z\u00E1n p\u0159\u00EDzniv\u00FD vliv sezaminu na metabolismus lipid\u016F vedouc\u00ED ke zv\u00FD\u0161en\u00E9 hladin\u011B DHA. Tento pozitivn\u00ED efe"@cs . "In vitro cultivated Atlantic salmon (Salmo salar L.), hepatocytes were incubated without or with a mixture of sesamin and episesamin in order to test for possible effects on lipid metabolism. Sesamin/episesamin exposure (0.05 mM, final concentration) led to increased elongation and desaturation of 14C 18:3n-3 to docosahexaenoic acid (14C 22:6n-3, DHA, P0.01) and down regulated gene expression of 6 and 5 desaturases compared to control treatment. Sesamin/episesamin further increased the hepatocytes capacity for fatty acid -oxidation of 14C 18:3n-3 (P0.01) to the 14C acid soluble products, acetate, malate and oxaloacetate, in agreement with an increased gene expression of carnitine palmitoyltransferase I. Also the gene expression of cluster of differentiation 36 was upregulated and the expression of scavenger receptor type B, peroxisome proliferator-activated receptors a and c were downregulated. The amount of triacylglycerols secreted by the cells tended to be lower in the sesamin/episesamin incubated"@en . "Sesamin Increases Alpha-Linolenic Acid Conversion to Docosahexaenoic Acid in Atlantic Salmon (Salmo salar L.) Hepatocytes: Role of Altered Gene Expression" . "Sezamin zv\u00FD\u0161uje konverzi alfa-linolenov\u00E9 kyseliny na kyselinu dokosahexaenovou v hepatocytech lososa obecn\u00E9ho (Salmo salar L.): Vliv na zm\u011Bnu genov\u00E9 exprese"@cs . . . "\u00D8stbye, T. K." . "Sesamin Increases Alpha-Linolenic Acid Conversion to Docosahexaenoic Acid in Atlantic Salmon (Salmo salar L.) Hepatocytes: Role of Altered Gene Expression"@en . "\u017Dl\u00E1bek, Vladim\u00EDr" . "RIV/60076658:12610/08:00008924!RIV09-MSM-12610___" . . "Pickov\u00E1, Jana" . . . "Lipids" . "12610" . . "Hepatocytes; sesamin; desaturation; -linolenic acid; docosahexaenoic acid"@en . "43" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "0024-4201" . "Kamal-Eldin, A." . "In vitro cultivated Atlantic salmon (Salmo salar L.), hepatocytes were incubated without or with a mixture of sesamin and episesamin in order to test for possible effects on lipid metabolism. Sesamin/episesamin exposure (0.05 mM, final concentration) led to increased elongation and desaturation of 14C 18:3n-3 to docosahexaenoic acid (14C 22:6n-3, DHA, P0.01) and down regulated gene expression of 6 and 5 desaturases compared to control treatment. Sesamin/episesamin further increased the hepatocytes capacity for fatty acid -oxidation of 14C 18:3n-3 (P0.01) to the 14C acid soluble products, acetate, malate and oxaloacetate, in agreement with an increased gene expression of carnitine palmitoyltransferase I. Also the gene expression of cluster of differentiation 36 was upregulated and the expression of scavenger receptor type B, peroxisome proliferator-activated receptors a and c were downregulated. The amount of triacylglycerols secreted by the cells tended to be lower in the sesamin/episesamin incubated" . . . "6"^^ . "10"^^ . "Sesamin Increases Alpha-Linolenic Acid Conversion to Docosahexaenoic Acid in Atlantic Salmon (Salmo salar L.) Hepatocytes: Role of Altered Gene Expression" . . . .