"Environmental Toxicology and Pharmacology" . . . "38" . "Wu, Yan-Hua" . "Ni, Zhao-Hui" . "http://www.sciencedirect.com/science/article/pii/S1382668914001562" . "Li, Zhihua" . "Li, Zhihua" . . "Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride"@en . . "RIV/60076658:12520/14:43886815" . "Mercury is a prominent environmental contaminant that causes endocrine disorder to human and other organisms. But little is known about the response of the thyroid functions and hypothalamic-pituitary-thyroid (HPT) axis to mercury in teleosts and the few studies that are available have not yielded consistent results. In this study, expression profiles of corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5), thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta) genes were determined in whole-body of Chinese rare minnow (Gobiocypris Torus) larvae after exposure to different levels of Hg2+ (0, 0.1 and 0.3 mg/l) for 4 days, as well as the thyroid hormones (THs) levels. Moreover, the 96-h lethal concentration of Hg2+ on rare minnow larvae was determined as 0.32 mg/l. The results showed that crh, tg, tr alpha and tr beta mRNA levels were significantly up-regulated in the larvae, but the gene expression of tsh beta and slc5a5 was not significantly changed in our study. Besides, the THs levels increased in the whole-body of fish, especially the thyroxine (T4) level. The above results indicated that Hg2+ could alter some genes expression in the HPT axis which could be used as the potential biomarkers for evaluating the environmental Hg2+-induced stress in fish."@en . . . . "Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride" . "P(ED2.1.00/01.0024), P(LO1205)" . . "RIV/60076658:12520/14:43886815!RIV15-MSM-12520___" . "1" . . . "1382-6689" . "Li, Ping" . "12520" . "2"^^ . "Li, Ping" . "7"^^ . . . "Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride"@en . "Li, Yun-Feng" . . "Mercury is a prominent environmental contaminant that causes endocrine disorder to human and other organisms. But little is known about the response of the thyroid functions and hypothalamic-pituitary-thyroid (HPT) axis to mercury in teleosts and the few studies that are available have not yielded consistent results. In this study, expression profiles of corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5), thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta) genes were determined in whole-body of Chinese rare minnow (Gobiocypris Torus) larvae after exposure to different levels of Hg2+ (0, 0.1 and 0.3 mg/l) for 4 days, as well as the thyroid hormones (THs) levels. Moreover, the 96-h lethal concentration of Hg2+ on rare minnow larvae was determined as 0.32 mg/l. The results showed that crh, tg, tr alpha and tr beta mRNA levels were significantly up-regulated in the larvae, but the gene expression of tsh beta and slc5a5 was not significantly changed in our study. Besides, the THs levels increased in the whole-body of fish, especially the thyroxine (T4) level. The above results indicated that Hg2+ could alter some genes expression in the HPT axis which could be used as the potential biomarkers for evaluating the environmental Hg2+-induced stress in fish." . "Chen, Lu" . . "[DA0AE14BE0B9]" . "6"^^ . "Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride" . "10.1016/j.etap.2014.07.002" . . "000341468900036" . "Gene expression; Hypothalamic-pituitary-thyroid axis; Thyroid hormone; Chinese rare minnow; Mercury"@en . "2241" . . . "NL - Nizozemsko" .