. . "Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole" . "1532-0456" . "Grabic, Roman" . "Li, Zhihua" . . "000280902400020" . . "7"^^ . "Li, Ping" . . . . "Fish; Oxidative stress; Residual fungicide; Glutathione"@en . . "Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole"@en . "12520" . "Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole"@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "5"^^ . . . . "152" . . "5"^^ . . . "RIV/60076658:12520/10:00011413" . "Rand\u00E1k, Tom\u00E1\u0161" . . "Recently, residual fungicides are generally recognized as relevant sources of aquatic environmental pollutants. However, the toxicological effects of these contaminants have not been adequately researched. In this study, the chronic effect of PCZ, a triazole-containing fungicide commonly present in aquatic environment, on GSH-related antioxidant system and oxidative stress indices of rainbow trout (Oncorhynchus mykiss) were investigated. Fish were exposed at sub-lethal concentrations of PCZ (0.2, 50 and 500 mu g/L) for 7, 20 and 30 days. GSH levels and GSH-related enzyme activities, including GPx, GR and GST, were quantified in three tissues liver, gill and muscle. The levels of LPO and CP were also measured as makers of oxidative damage. In addition, the correlations of the measured parameters in various tissues were evaluated by using PCA. The results of this study indicate that chronic exposure of PCZ has resulted in different responses in various tissues and the gill was the most sensitive tissue;"@en . "RIV/60076658:12520/10:00011413!RIV11-MZP-12520___" . "3" . "Li, Zhihua" . "P(SP/2E7/229/07), Z(MSM6007665809)" . "\u017Dl\u00E1bek, Vladim\u00EDr" . "Recently, residual fungicides are generally recognized as relevant sources of aquatic environmental pollutants. However, the toxicological effects of these contaminants have not been adequately researched. In this study, the chronic effect of PCZ, a triazole-containing fungicide commonly present in aquatic environment, on GSH-related antioxidant system and oxidative stress indices of rainbow trout (Oncorhynchus mykiss) were investigated. Fish were exposed at sub-lethal concentrations of PCZ (0.2, 50 and 500 mu g/L) for 7, 20 and 30 days. GSH levels and GSH-related enzyme activities, including GPx, GR and GST, were quantified in three tissues liver, gill and muscle. The levels of LPO and CP were also measured as makers of oxidative damage. In addition, the correlations of the measured parameters in various tissues were evaluated by using PCA. The results of this study indicate that chronic exposure of PCZ has resulted in different responses in various tissues and the gill was the most sensitive tissue;" . "Li, Ping" . "Comparative Biochemistry and Physiology C - Toxicology and Pharmacology" . "Modulation of glutathione-related antioxidant defense system of fish chronically treated by the fungicide propiconazole" . . . "[979703E4B303]" . . . "272334" . .