"Physiological condition status and Muscle based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine"@en . "P(SP/2E7/229/07), Z(MSM6007665809)" . "30" . "0260-437X" . "[EBB4B1A76E20]" . . . "3" . "12520" . "Vel\u00ED\u0161ek, Josef" . "Physiological condition status and Muscle based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine" . "7"^^ . . "Fish; residual pharmaceutical; oxidative stress; condition factor; hepatosomatic index; RNA-DNA ratio; Na+-K+-ATPase"@en . . . . "000277524000002" . "Rand\u00E1k, Tom\u00E1\u0161" . "Grabic, Roman" . . "Li, Zhihua" . "The chronic toxic effects of carbamazepine (CBZ) on rainbow trout were investigated. Fish were exposed at sublethal concentrations of CBZ (1.0 \u03BCg.l-1, 0.2 mg l-1 and 2.0 mg.l-1) for 42 days. Compared with the control, there was a significant lower (P < 0.05) condition factor in fish exposed at the highest concentration of CBZ (2.0 mg.l-1), but the hepatosomatic indices in all groups were not significant changes. At lower CBZ concentration (1.0 \u03BCg.l-1, 0.2 mg.l-1), the antioxidant enzyme activities were induced slightly, except catalase, while at the highest concentration (2.0 mg.l-1) oxidative stress was apparent as reflected by the significant higher lipid peroxidation and protein carbonyls in the fish muscle, associated with a significant inhibition of antioxidant enzymes activities. Moreover, energy metabolic parameters (RNA-DNA ratio, Na+-K+-ATPase) were significantly inhibited in muscle of the fish exposed at the highest concentration (2.0 mg.l-1), compared with the control."@en . . . "M\u00E1chov\u00E1, Jana" . . "Journal of Applied Toxicology" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Physiological condition status and Muscle based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine" . . "The chronic toxic effects of carbamazepine (CBZ) on rainbow trout were investigated. Fish were exposed at sublethal concentrations of CBZ (1.0 \u03BCg.l-1, 0.2 mg l-1 and 2.0 mg.l-1) for 42 days. Compared with the control, there was a significant lower (P < 0.05) condition factor in fish exposed at the highest concentration of CBZ (2.0 mg.l-1), but the hepatosomatic indices in all groups were not significant changes. At lower CBZ concentration (1.0 \u03BCg.l-1, 0.2 mg.l-1), the antioxidant enzyme activities were induced slightly, except catalase, while at the highest concentration (2.0 mg.l-1) oxidative stress was apparent as reflected by the significant higher lipid peroxidation and protein carbonyls in the fish muscle, associated with a significant inhibition of antioxidant enzymes activities. Moreover, energy metabolic parameters (RNA-DNA ratio, Na+-K+-ATPase) were significantly inhibited in muscle of the fish exposed at the highest concentration (2.0 mg.l-1), compared with the control." . . "6"^^ . . . "278934" . . . . . . "6"^^ . "RIV/60076658:12520/10:00011403!RIV11-MZP-12520___" . . . . "Physiological condition status and Muscle based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine"@en . . . "Li, Zhihua" . "RIV/60076658:12520/10:00011403" . "\u017Dl\u00E1bek, Vladim\u00EDr" .