. "0016-6480" . "12520" . "166" . "Sures, B." . "Z(MSM6007665809)" . "7"^^ . "Kloas, W." . "[8BC249BFC268]" . . . "000275781800003" . "Kroupov\u00E1, Hana" . . . . "Naturally-induced endocrine disruption by the parasite Ligula intestinalis (Cestoda) in roach (Rutilus rutilus)"@en . . "Parasitisation by the tapeworm Ligula intestinalis suppressed gonadal development in both genders of roach (Rutilus rutilus). Analysis of plasma sex steroids revealed substantially lower levels of 17 beta-oestradiol (E2) and 11-ketotestosterone (11-KT) in infected females as well as E2, 11-KT, and testosterone in infected males. In both, infected females and males, expression of the oestrogen dependent genes such as vitellogenin and brain-type aromatase in liver and brain was reduced. Furthermore, liver expression of oestrogen receptor 1 was reduced in infected females but not in males, whereas expression of oestrogen receptor 2a was up-regulated in both genders. Further, insulin-like growth factor 1 (IGF 1) mRNA in the liver was increased in infected females but not in males. The present results provide basic knowledge of the endocrine system in L. intestinalis-infected roach and clearly demonstrate that parasites can cause endocrine disruption in fish." . "Endocrine disruption; Tapeworm; Reproduction; Biomarker; Fish; Roach; Rutilus rutilus; Vitellogenin; Aromatase; Oestrogens; Androgens"@en . . "RIV/60076658:12520/10:00011400!RIV11-MSM-12520___" . . "General and Comparative Endocrinology" . . "Parasitisation by the tapeworm Ligula intestinalis suppressed gonadal development in both genders of roach (Rutilus rutilus). Analysis of plasma sex steroids revealed substantially lower levels of 17 beta-oestradiol (E2) and 11-ketotestosterone (11-KT) in infected females as well as E2, 11-KT, and testosterone in infected males. In both, infected females and males, expression of the oestrogen dependent genes such as vitellogenin and brain-type aromatase in liver and brain was reduced. Furthermore, liver expression of oestrogen receptor 1 was reduced in infected females but not in males, whereas expression of oestrogen receptor 2a was up-regulated in both genders. Further, insulin-like growth factor 1 (IGF 1) mRNA in the liver was increased in infected females but not in males. The present results provide basic knowledge of the endocrine system in L. intestinalis-infected roach and clearly demonstrate that parasites can cause endocrine disruption in fish."@en . . . . "Naturally-induced endocrine disruption by the parasite Ligula intestinalis (Cestoda) in roach (Rutilus rutilus)" . "6"^^ . "Naturally-induced endocrine disruption by the parasite Ligula intestinalis (Cestoda) in roach (Rutilus rutilus)" . . . . "RIV/60076658:12520/10:00011400" . . . "273879" . "Frank, S. N." . . . "Wuertz, S." . "2" . . "1"^^ . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . . "Trubiroha, A." . "Naturally-induced endocrine disruption by the parasite Ligula intestinalis (Cestoda) in roach (Rutilus rutilus)"@en .