. "3" . "000268079600007" . "1751-7311" . "The present study aimed to evaluate some cytochrome P450 metabolic enzyme activities in hepatic microsomes prepared from entire male pigs (uncastrated pigs), surgically castrated pigs and pigs immunized against gonadotropin-releasing hormone (immunocastrated pigs). The activities of the following enzymes were measured: ethoxyresorufin O-deethylase (EROD, CYP1A1/1A2), methoxyresorufin O-deethylase (MROD, CYP1A2), pentoxyresorufin O-depentylase (PROD, CYP2B), coumarin hydroxylase (COH, CYP2A) and p-nitrophenol hydroxylase (PNPH, CYP2A/2E1). The total cytochrome P450 contents were not affected by either surgical or immunocastration. Hepatic microsomal activities for EROD, PROD, COH and PNPH were lower in entire male pigs compared with surgically castrated and immunocastrated pigs ( P,0.05). Surgically and immunocastrated male pigs were similar with respect to EROD, MROD, PROD and COH activities ( P.0.05), whereas surgically castrated pigs exhibited lower PNPH activity compared with immunocastrated pigs (" . "Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration"@en . "327185" . "Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration" . "Z(MSM6007665809)" . "[505E029105E9]" . "Animal" . "Castration; cytochrome P450; porcine liver microsomes; steroids"@en . . "1"^^ . "Madej, A." . . . "Chen, G." . . "RIV/60076658:12520/09:00010321" . . . . "\u017Dl\u00E1bek, Vladim\u00EDr" . "4"^^ . . . "RIV/60076658:12520/09:00010321!RIV10-MSM-12520___" . "12520" . "Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration"@en . "9" . "Zamaratskaia, Galia" . . . . . . "The present study aimed to evaluate some cytochrome P450 metabolic enzyme activities in hepatic microsomes prepared from entire male pigs (uncastrated pigs), surgically castrated pigs and pigs immunized against gonadotropin-releasing hormone (immunocastrated pigs). The activities of the following enzymes were measured: ethoxyresorufin O-deethylase (EROD, CYP1A1/1A2), methoxyresorufin O-deethylase (MROD, CYP1A2), pentoxyresorufin O-depentylase (PROD, CYP2B), coumarin hydroxylase (COH, CYP2A) and p-nitrophenol hydroxylase (PNPH, CYP2A/2E1). The total cytochrome P450 contents were not affected by either surgical or immunocastration. Hepatic microsomal activities for EROD, PROD, COH and PNPH were lower in entire male pigs compared with surgically castrated and immunocastrated pigs ( P,0.05). Surgically and immunocastrated male pigs were similar with respect to EROD, MROD, PROD and COH activities ( P.0.05), whereas surgically castrated pigs exhibited lower PNPH activity compared with immunocastrated pigs ("@en . "9"^^ .