"Casselman, A." . . "1544-9173" . "TRANSCRIPTIONAL REPRESSOR; DROSOPHILA-MELANOGASTER; ANTHERAEA-PERNYI; GENE-EXPRESSION; POLARIZED-LIGHT; PERIOD; BRAIN; PHOTORECEPTOR; NEURONS; INSECT"@en . "6" . . . . "1"^^ . "Emery, P." . "Plos Biology" . . . . . . . "Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation"@en . . "RIV/60076658:12310/08:00009754" . "Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation"@cs . . . . "7"^^ . . . "Yuan, Q." . "Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation"@cs . "[2E5186CE21D4]" . "Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation" . . "Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation"@en . . "\u0160auman, Ivo" . "12310" . "Zhu, H." . "RIV/60076658:12310/08:00009754!RIV09-MSM-12310___" . "Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation"@cs . "The circadian clock plays a vital role in monarch butterfly (Danaus plexippus) migration by providing the timing component of time-compensated sun compass orientation, a process that is important for successful navigation. We therefore evaluated the monarch clockwork by focusing on the functions of a Drosophila-like cryptochrome (cry), designated cry1, and a vertebrate-like cry, designated cry2, that are both expressed in the butterfly and by placing these genes in the context of other relevant clock genes in vivo. We found that similar temporal patterns of clock gene expression and protein levels occur in the heads, as occur in DpN1 cells, of a monarch cell line that contains a light-driven clock. CRY1 mediates TIMELESS degradation by light in DpN1 cells, and a light-induced TIMELESS decrease occurs in putative clock cells in the pars lateralis (PL) in the brain. Moreover, monarch cry1 transgenes partially rescue both biochemical and behavioral light-input defects in cry(b) mutant Drosophila. CRY2 is" . "18"^^ . "Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation" . "361612" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "000254928300014" . . "The circadian clock plays a vital role in monarch butterfly (Danaus plexippus) migration by providing the timing component of time-compensated sun compass orientation, a process that is important for successful navigation. We therefore evaluated the monarch clockwork by focusing on the functions of a Drosophila-like cryptochrome (cry), designated cry1, and a vertebrate-like cry, designated cry2, that are both expressed in the butterfly and by placing these genes in the context of other relevant clock genes in vivo. We found that similar temporal patterns of clock gene expression and protein levels occur in the heads, as occur in DpN1 cells, of a monarch cell line that contains a light-driven clock. CRY1 mediates TIMELESS degradation by light in DpN1 cells, and a light-induced TIMELESS decrease occurs in putative clock cells in the pars lateralis (PL) in the brain. Moreover, monarch cry1 transgenes partially rescue both biochemical and behavioral light-input defects in cry(b) mutant Drosophila. CRY2 is"@en . "Reppert, M." . . . "1" . . "P(LC07032)" . "Emery-Le, M." .