"RIV/60076658:12220/08:00009544!RIV09-MZE-12220___" . "396628" . . "4"^^ . . "3"^^ . . "0022-5142" . . . "88" . . "4"^^ . "RIV/60076658:12220/08:00009544" . "Sporadic incidence of factor XI deficiency in Holstein cattle" . "Ojedin\u011Bl\u00FD v\u00FDskyt deficience faktoru XI u hol\u0161t\u00FDnsk\u00E9ho skotu"@cs . . . . "12220" . . . "Holstein; factor XI; exon 12; exon 9; PCR"@en . . . "\u010C\u00EDtek, Jind\u0159ich" . "Factor XI (FIX) is a plasma serine protease involved in the early activation of the blood coagulation cascade. A survey of Holstein cattle, and Czech Simmental cattle crossed with Holstein, was done to determine whether animals heterozygous for FXI deficiency were present. Mutations in exon 12 and exon 9 were analysed. The method used was based on the polymerase chain reaction and subsequent distinction of the lenght of fragments.In the panel analysed (279 Holstein and 30 Simmentals), one heterozygous carrier of the recessive allele in exon 12 ( a German Holstein cow) was found. Some authors have found that the frequency is high in some breeding lines and low in others. Evidently the lines in our \u00E4nalysis are part of the group with a low frequency. In exon 9, all the animals (100 Holstein and 52 Simmentals) were honozygous wild type. To date, the mutation in exon 9 has been found only in Japanese black cattle, and its breed-specific occurrence was therefore not disconfirmed by our assay. Our result"@en . . . "[09CDD3EF43B1]" . . . "000262541700002" . . "\u0158ehout, V\u00E1clav" . "Factor XI (FIX) is a plasma serine protease involved in the early activation of the blood coagulation cascade. A survey of Holstein cattle, and Czech Simmental cattle crossed with Holstein, was done to determine whether animals heterozygous for FXI deficiency were present. Mutations in exon 12 and exon 9 were analysed. The method used was based on the polymerase chain reaction and subsequent distinction of the lenght of fragments.In the panel analysed (279 Holstein and 30 Simmentals), one heterozygous carrier of the recessive allele in exon 12 ( a German Holstein cow) was found. Some authors have found that the frequency is high in some breeding lines and low in others. Evidently the lines in our \u00E4nalysis are part of the group with a low frequency. In exon 9, all the animals (100 Holstein and 52 Simmentals) were honozygous wild type. To date, the mutation in exon 9 has been found only in Japanese black cattle, and its breed-specific occurrence was therefore not disconfirmed by our assay. Our result" . "JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE" . "P(QF3012), S, Z(MSM6007665806)" . . "Hanusov\u00E1, Lenka" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "12" . "Sporadic incidence of factor XI deficiency in Holstein cattle" . "Sporadic incidence of factor XI deficiency in Holstein cattle"@en . . "Sporadic incidence of factor XI deficiency in Holstein cattle"@en . . "Vrabcov\u00E1, P." . . "Faktor XI (FIX) je plazmov\u00E1 serinov\u00E1 prote\u00E1za, zahrnut\u00E1 do \u010Dasn\u00E9 aktivace kask\u00E1dy krevn\u00ED sr\u00E1\u017Elivosti. Byl proveden pr\u016Fzkum u hol\u0161t\u00FDnsk\u00E9ho skotu a k\u0159\u00ED\u017Eenc\u016F \u010Desk\u00E9ho strakat\u00E9ho skotu s hol\u0161t\u00FDnsk\u00FDm skotem s c\u00EDlem stanovit, zda se zde vyskytuj\u00ED heterozygoti rpo deficiency FXI"@cs . "Ojedin\u011Bl\u00FD v\u00FDskyt deficience faktoru XI u hol\u0161t\u00FDnsk\u00E9ho skotu"@cs .