"RIV/60076658:12110/10:00012128" . . "Valeriana officinalis; valerian; chemical constituents; alkaloids; terpenes - valepotriates"@en . "Valerian is used against sleeping disorders, restlessness and anxiety. Valerian seems only to work when taken over longer periods (several weeks). Some studies have demonstrated that valerian extracts interact with the GABA and benzodiazepine receptors. Valerian is also used traditionally to treat gastrointestinal pain and spastic colitis. Long term safety studies are missing. Valerian contains over 150 chemical constituents and many of them are physiologically active, mainly pyridine alkaloids, some organic acids and terpenes, especially so called valepotriates, esterified iridoid-monoterpenes. As valepotriates may be potential mutagens, valerian should only be used after consultation with a physician. Valerian medication is sometimes recommended as first line when benefit-risk relation requires so. Valerian is often indicated as transition medication during discontinuation processes involving bromazepam, clonazepam and diazepam, among others." . . "Pato\u010Dka, Ji\u0159\u00ED" . . "RIV/60076658:12110/10:00012128!RIV11-MSM-12110___" . "Biomedically relevant chemical constituents of Valeriana officinalis" . "8"^^ . . . . "Biomedically relevant chemical constituents of Valeriana officinalis" . . "CZ - \u010Cesk\u00E1 republika" . "Journal of Applied Biomedicine" . . "Biomedically relevant chemical constituents of Valeriana officinalis"@en . . . "8" . . "1214-021X" . "Biomedically relevant chemical constituents of Valeriana officinalis"@en . "000274244600002" . . "12110" . "P(QH81160), V" . "1"^^ . "248948" . "[728CF950BD70]" . "2"^^ . . . "Jakl, Ji\u0159\u00ED" . . "1" . "Valerian is used against sleeping disorders, restlessness and anxiety. Valerian seems only to work when taken over longer periods (several weeks). Some studies have demonstrated that valerian extracts interact with the GABA and benzodiazepine receptors. Valerian is also used traditionally to treat gastrointestinal pain and spastic colitis. Long term safety studies are missing. Valerian contains over 150 chemical constituents and many of them are physiologically active, mainly pyridine alkaloids, some organic acids and terpenes, especially so called valepotriates, esterified iridoid-monoterpenes. As valepotriates may be potential mutagens, valerian should only be used after consultation with a physician. Valerian medication is sometimes recommended as first line when benefit-risk relation requires so. Valerian is often indicated as transition medication during discontinuation processes involving bromazepam, clonazepam and diazepam, among others."@en . . . .