"8" . "000274244600003" . "Alternative haematotoxicological testing" . "Alternative haematotoxicological testing" . . "CZ - \u010Cesk\u00E1 republika" . . "V" . "1"^^ . . "12110" . "Alternative haematotoxicological testing"@en . . . . . . . "4"^^ . "1" . . "[ACA598B2B937]" . . "Berger, Josef" . . "IN-VITRO; COMPUTATIONAL TOXICOLOGY; ANTIFOULING COMPOUNDS MICRONUCLEUS TEST; ANTICANCER DRUGS; HEMOCYTES; TOXICITY; ASSAY; RESPONSES; IMMUNOTOXICITY"@en . "246032" . "Alternative haematotoxicological testing"@en . . . . "Standard haematological procedures in preclinical subchronic and chronic toxicity studies are carried out on dogs, rats and other mammals. In vitro clonic assays CFU-GM, BFU-E, CFU-E, CFU-Mgkr and pluripotent stem cells are used in screening candidate compounds to predict acute cytopenias, but they are not able to reveal the risk of suppression which can develop after repeated administration. No in silico studies have yet been published in haematotoxicology. More recent haematotoxicological in vivo models represent invertebrates: they can be used in both ecotoxicology and in the screening of myelotoxicity."@en . . . . "RIV/60076658:12110/10:00012115!RIV11-MSM-12110___" . . "Standard haematological procedures in preclinical subchronic and chronic toxicity studies are carried out on dogs, rats and other mammals. In vitro clonic assays CFU-GM, BFU-E, CFU-E, CFU-Mgkr and pluripotent stem cells are used in screening candidate compounds to predict acute cytopenias, but they are not able to reveal the risk of suppression which can develop after repeated administration. No in silico studies have yet been published in haematotoxicology. More recent haematotoxicological in vivo models represent invertebrates: they can be used in both ecotoxicology and in the screening of myelotoxicity." . . "RIV/60076658:12110/10:00012115" . "Journal of Applied Biomedicine" . "1214-021X" . "1"^^ .