"1"^^ . . . "1214-021X" . . . . . "The circadian rhythms of the haemato-immune system seem to be synchronized by two clocks: the hypothalamic endogenous, and the exogenous which is based on environmental stimuli. The suprachiasmatic nucleus is not only a circadian clock, it also synchronizes peripheral oscillators and integrates light information through the retino-hypothalamic tract. The role of the ?peripheral? clock genes in mature leucocytes still remains an unanswered question as well as the role of clock proteins in ?non-clock? physiology. The circadian rhythms may be a basis for circannual variations, although the molecular bases of such rhythms remain a mystery. There are several hormones which have a significant impact on haematological characteristics; the finding of a lower superoxide release from granulocytes at higher melatonin levels opens up new research opportunities for melatonin therapy. Discrepancies between circadian changes in mRNAs and the appropriate protein participating in haemocoagulation and fibrinolysis may"@en . "1"^^ . . "Advances in chronohaematology" . "Advances in chronohaematology" . "Berger, Josef" . . "P\u0159ehledn\u00FD \u010Dl\u00E1nek v\u011Bnovan\u00FD pokrok\u016Fm v chronohematologii v posledn\u00EDch letech. Jsou nastoleny ot\u00E1zky t\u00FDkaj\u00EDc\u00ED se hematoimunitn\u00EDho syst\u00E9mu, jeho regulace na urovni cel\u00E9ho organismu i na \u00FArovn aktivity gen\u016F. Problematika regulace biorytm\u016F p\u0159i hemokoagulaci a fibrinol\u00FDze z\u016Fst\u00E1v\u00E1 st\u00E1le ve velk\u00E9 m\u00ED\u0159e neobjasn\u011Bna. Endogenn\u00ED slo\u017Eka rytm\u016F usnad\u0148uje reparativn\u00ED procesy b\u011Bhem subjektivn\u00ED noci."@cs . "RIV/60076658:12110/08:00009098!RIV09-MSM-12110___" . "Advances in chronohaematology"@en . "[DF65E0C6D546]" . . "12110" . "355012" . . . "Advances in chronohaematology"@en . "CZ - \u010Cesk\u00E1 republika" . . "RIV/60076658:12110/08:00009098" . "Journal of Applied Biomedicine" . . "6" . . . . "Pokroky v chronohematologii"@cs . "V" . "The circadian rhythms of the haemato-immune system seem to be synchronized by two clocks: the hypothalamic endogenous, and the exogenous which is based on environmental stimuli. The suprachiasmatic nucleus is not only a circadian clock, it also synchronizes peripheral oscillators and integrates light information through the retino-hypothalamic tract. The role of the ?peripheral? clock genes in mature leucocytes still remains an unanswered question as well as the role of clock proteins in ?non-clock? physiology. The circadian rhythms may be a basis for circannual variations, although the molecular bases of such rhythms remain a mystery. There are several hormones which have a significant impact on haematological characteristics; the finding of a lower superoxide release from granulocytes at higher melatonin levels opens up new research opportunities for melatonin therapy. Discrepancies between circadian changes in mRNAs and the appropriate protein participating in haemocoagulation and fibrinolysis may" . "Pokroky v chronohematologii"@cs . "circadian; seasonal; clock gene; haemostasis; immunity; melatonin; superoxide"@en . . "8"^^ . "2" . .