. . . "RIV/49777513:23520/13:43920563" . . "V\u00FDb\u011Br optim\u00E1ln\u00EDho d\u00E1rce s vyu\u017Eit\u00EDm dat DNA typizace" . "[612AFAF21634]" . "Optimal donor search using DNA typing data"@en . "Prototyp je pl\u00E1novan\u00FDm v\u00FDstupem projektu TA01010342, jeho\u017E ekonomick\u00FD p\u0159\u00EDnos je definov\u00E1n jako relevantn\u00ED pod\u00EDl p\u0159\u00EDnos\u016F projektu. V\u00FDsledek umo\u017En\u00ED zv\u00FD\u0161en\u00ED objemu a zisku v aplikovan\u00E9m v\u00FDzkumu, p\u0159esn\u011Bj\u0161\u00ED vyhled\u00E1n\u00ED vhodn\u00E9ho d\u00E1rce, a t\u00EDm finan\u010Dn\u00ED \u00FAsporu a urychlen\u00ED transplanta\u010Dn\u00EDho procesu." . . . "http://www.kky.zcu.cz/cs/sw/vyhledavani_DNA" . . . "V\u00FDb\u011Br optim\u00E1ln\u00EDho d\u00E1rce s vyu\u017Eit\u00EDm dat DNA typizace"@cs . . . "probabilistic models; genotype; haplotype; bone marrow donors search"@en . "This is a prototype solution for potentially match of unrelated stem cell donors utilizing probabilistic models of haplotypes and genotypes and patient-donor HLA match. Solutions include implementation of the required antigens decomposition for all loci (HLA-A/B/C/DRB1/DQB1) depended on typing resolution (NMDP, MAC codes), dealing with the serological data, identified probability models of all possible haplotypes and genotypes (by EM algorithm) and search criteria options (e.g. 10/10 match, 9/10 HLA-A mismatch, 7/8 HLA-C mismatch)."@en . "3"^^ . . . "3"^^ . "DNA prototyp" . . "P(TA01010342)" . . "V\u00FDb\u011Br optim\u00E1ln\u00EDho d\u00E1rce s vyu\u017Eit\u00EDm dat DNA typizace"@cs . "Houdov\u00E1, Lucie" . "Jedn\u00E1 se o prototypov\u00E9 \u0159e\u0161en\u00ED vyhled\u00E1v\u00E1n\u00ED potenci\u00E1ln\u011B shodn\u00FDch d\u00E1rc\u016F kostn\u00ED d\u0159en\u011B vyu\u017Eivaj\u00EDc\u00ED pravd\u011Bpodobnostn\u00ED modely haplotyp\u016F a genotyp\u016F nep\u0159\u00EDbuzn\u00FDch jedinc\u016F a HLA shod pacient-d\u00E1rce. \u0158e\u0161en\u00ED zahrnuje implementaci pot\u0159ebn\u00E9ho rozkladu variant antigen\u016F pro v\u0161echny lokusy (HLA-A/B/C/DRB1/DQB1) v z\u00E1vislosti na rozli\u0161en\u00ED typizace (rozklad NMDP, MAC k\u00F3d\u016F), vypo\u0159\u00E1d\u00E1n\u00ED se se s\u00E9rologick\u00FDmi daty, identifikovan\u00E9 pravd\u011Bpodobnostn\u00ED modely v\u0161ech mo\u017En\u00FDch haplotyp\u016F a genotyp\u016F pomoc\u00ED EM algoritmu, mo\u017Enosti volby po\u017Eadovan\u00FDch krit\u00E9ri\u00ED (nap\u0159. po\u017Eadovanou HLA shodu 10/10, 9/10 HLA-A mismatch (neshoda) , 7/8 HLA-C mismatch) ."@cs . . "115190" . "23520" . "Eduard Jane\u010Dek, Univerzitn\u00ED 8, 301 00 Plze\u0148, email: janecek@kky.zcu.cz, tel. +420 377 632 506" . . "Georgiev, Daniel" . . "Jedn\u00E1 se o prototypov\u00E9 \u0159e\u0161en\u00ED vyhled\u00E1v\u00E1n\u00ED potenci\u00E1ln\u011B shodn\u00FDch d\u00E1rc\u016F kostn\u00ED d\u0159en\u011B vyu\u017Eivaj\u00EDc\u00ED pravd\u011Bpodobnostn\u00ED modely haplotyp\u016F a genotyp\u016F nep\u0159\u00EDbuzn\u00FDch jedinc\u016F a HLA shod pacient-d\u00E1rce. \u0158e\u0161en\u00ED zahrnuje implementaci pot\u0159ebn\u00E9ho rozkladu variant antigen\u016F pro v\u0161echny lokusy (HLA-A/B/C/DRB1/DQB1) v z\u00E1vislosti na rozli\u0161en\u00ED typizace (rozklad NMDP, MAC k\u00F3d\u016F), vypo\u0159\u00E1d\u00E1n\u00ED se se s\u00E9rologick\u00FDmi daty, identifikovan\u00E9 pravd\u011Bpodobnostn\u00ED modely v\u0161ech mo\u017En\u00FDch haplotyp\u016F a genotyp\u016F pomoc\u00ED EM algoritmu, mo\u017Enosti volby po\u017Eadovan\u00FDch krit\u00E9ri\u00ED (nap\u0159. po\u017Eadovanou HLA shodu 10/10, 9/10 HLA-A mismatch (neshoda) , 7/8 HLA-C mismatch) ." . . . "Fetter, Milo\u0161" . . "Optimal donor search using DNA typing data"@en . "RIV/49777513:23520/13:43920563!RIV14-TA0-23520___" . . "V\u00FDb\u011Br optim\u00E1ln\u00EDho d\u00E1rce s vyu\u017Eit\u00EDm dat DNA typizace" . . .