. "RIV/49777513:23520/09:00501877!RIV10-MSM-23520___" . "0001-7213" . "Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension" . "Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension"@en . "\u0160v\u00EDglerov\u00E1, Jitka" . . "Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension" . "\u0160tengl, Milan" . "Acta Veterinaria Brno" . "23520" . . "8"^^ . . "Long-term hypertension in arteries leads to remodelling of the arterial wall. We focused on morphological changes in the wall of the subrenal aorta in rats suffering from arterial hypertension and chronic renal failure induced by 5/6 nephrectomy (NX). We quantified the area of the profile of the arterial lumen, the volume fraction of elastin and smooth muscle cells (SMC) in the tunica media, the thickness of the intima-media, the length density of elastin lamellae, the lamellar unit thickness and the lamellar number. Calcitonin gene related peptide (CGRP) was assayed in extracts of aortic tissue and in plasma. Ten days after the subtotal nephrectomy, the structure of the aorta of NX rats did not differ compared to control animals. Pronounced structural changes were observed ten weeks after 5/6 nephrectomy. The area of the lumen profile, the elastin volume fraction and the elastin lamellar number in the tunica media were all significantly higher (p < 0.001) in NX than in control animals. The SMC vo" . . "Tonar, Zbyn\u011Bk" . "6"^^ . . . . . "Mat\u011Bjka, V\u00EDt M." . "Kuncov\u00E1, Jitka" . . "histology; stereology; chronic renal failure; nephrectomy; quantitative microscopy"@en . . . "303574" . . "P(1M0510), P(GA106/09/0734), Z(MSM0021620819), Z(MSM4977751303)" . "2"^^ . . "78" . "4" . "CZ - \u010Cesk\u00E1 republika" . "[6DA2926C844F]" . . . . . "Kochov\u00E1, Petra" . . . "Long-term hypertension in arteries leads to remodelling of the arterial wall. We focused on morphological changes in the wall of the subrenal aorta in rats suffering from arterial hypertension and chronic renal failure induced by 5/6 nephrectomy (NX). We quantified the area of the profile of the arterial lumen, the volume fraction of elastin and smooth muscle cells (SMC) in the tunica media, the thickness of the intima-media, the length density of elastin lamellae, the lamellar unit thickness and the lamellar number. Calcitonin gene related peptide (CGRP) was assayed in extracts of aortic tissue and in plasma. Ten days after the subtotal nephrectomy, the structure of the aorta of NX rats did not differ compared to control animals. Pronounced structural changes were observed ten weeks after 5/6 nephrectomy. The area of the lumen profile, the elastin volume fraction and the elastin lamellar number in the tunica media were all significantly higher (p < 0.001) in NX than in control animals. The SMC vo"@en . "RIV/49777513:23520/09:00501877" . . . "Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension"@en .