"I, N, V" . "Vyu\u017Eit\u00ED endofenotyp\u016F v genetick\u00E9m v\u00FDzkumu schizofrenie" . "Vyu\u017Eit\u00ED endofenotyp\u016F v genetick\u00E9m v\u00FDzkumu schizofrenie" . . . "Vyu\u017Eit\u00ED endofenotyp\u016F v genetick\u00E9m v\u00FDzkumu schizofrenie"@cs . "Endophenotypes in genetic studies of schizophrenia"@en . "10"^^ . "Modern\u00EDmi metodami genetick\u00E9ho v\u00FDzkumu schizofrenie jsou celogenomov\u00E9 asocia\u010Dn\u00ED studie a hled\u00E1n\u00ED mikrodelec\u00ED/mikroduplikac\u00ED DNA. Takto mohou b\u00FDt v\u00FDznamn\u00E9 polymorfismy nalezeny, nezn\u00E1me v\u0161ak jejich roli v patogenezi onemocn\u011Bn\u00ED. Proto se pozornost obrac\u00ED ke genetick\u00E9mu vy\u0161et\u0159ov\u00E1n\u00ED endofenotyp\u016F schizofrenie. Endofenotyp je nej\u010Dast\u011Bji neurobiologick\u00E1 \u010Di neuropsychologick\u00E1 charakteristika asociovan\u00E1 s danou nemoc\u00ED, je d\u011Bdi\u010Dn\u00E1 a celo\u017Eivotn\u00ED a vyskytuje se tak\u00E9 u du\u0161evn\u011B zdrav\u00FDch p\u0159\u00EDbuzn\u00FDch pacienta. U schizofrenie jsou studov\u00E1ny zejm\u00E9na endofenotypy neurofyziologick\u00E9, neiromotorick\u00E9, neurokognitivn\u00ED, neuroanatomick\u00E9 a neurologick\u00E9. V tomto p\u0159ehledov\u00E9m \u010Dl\u00E1nku jsou nejv\u00FDznamn\u011Bj\u0161\u00ED endofenotypy schizofrenie pops\u00E1ny, zm\u00EDn\u011Bn je i jejich biologick\u00FD podklad a mo\u017En\u00E9 v\u00FDznamn\u00E9 genetick\u00E9 n\u00E1lezy. Probl\u00E9mem popisovan\u00E9ho v\u00FDzkumu je p\u0159edev\u0161\u00EDm skute\u010Dnost, \u017Ee schizofrenie je klinicky velmi heterogenn\u00ED a v\u00FDskyt endofenotyp\u016F se u jejich jednotliv\u00FDch forem m\u016F\u017Ee v\u00FDznamn\u011B li\u0161it. Budoucnost m\u00E1 multicentrick\u00FD mezin\u00E1rodn\u00ED vgenetick\u00FD v\u00FDzkum endofenotyp\u016F schizofrenie, kdy v\u0161ak ve\u0161ker\u00E9 procedury musej\u00ED b\u00FDt prov\u00E1d\u011Bny jednotn\u011B. Nalezen\u00ED a vysv\u011Btlen\u00ED genetick\u00E9ho podkladu schizofrenie m\u016F\u017Ee slou\u017Eit jejich l\u00E9\u010Db\u011B, prevenci i destigmatizaci onemocn\u011Bn\u00ED."@cs . "19510" . . "schizophrenia; genetics; endophenotype; ethiopathogenesis"@en . "Genome-wide association studies and studies of DNA microdeletions/ microduplications represent modern genetic research methods applied in schizophrenia. It is possible to find important genes and their polymorphisms by these procedures, but the findings do not clarify schizophrenia pathogenesis. That is why the genetic research into schizophrenia endophenotypes has recently been emphasized. Endophenotype is usually a neurobiological or neuropsychological marker associated with a certain disease, heritable and life-long, and also occurs in healthy relatives of the patients. Neurophysiological, neuromotoric, neurocognitive, neuroanatomical and neurological endophenotypes are studied in schizophrenia most frequently. In this review article, we mention the most important schizophrenia endophenotypes including their biological background, and relevant genetic findings. The problem is that schizophrenia is a clinically heterogenous mental disorder, so the appearance of individual endophenotypes in particular subgroups may be significantly different. A multisite international genetic research into schizophrenia endophenotypes seems to be promising, but the procedures must be performed uniformly in all centers. The finding and elucidation of the genetic background of schizophrenia may help in its treatment, prevention, and destigmatization."@en . . . "RIV/47813059:19510/12:#0000176" . . "179484" . "\u0160ilhan, Petr" . "Psychiatrie" . "RIV/47813059:19510/12:#0000176!RIV13-MSM-19510___" . "Vyu\u017Eit\u00ED endofenotyp\u016F v genetick\u00E9m v\u00FDzkumu schizofrenie"@cs . . . "Hos\u00E1k, Ladislav" . . . . "1211-7579" . "[B5FD57B451FF]" . "16" . . "Hos\u00E1kov\u00E1, Ji\u0159ina" . "CZ - \u010Cesk\u00E1 republika" . . . "Modern\u00EDmi metodami genetick\u00E9ho v\u00FDzkumu schizofrenie jsou celogenomov\u00E9 asocia\u010Dn\u00ED studie a hled\u00E1n\u00ED mikrodelec\u00ED/mikroduplikac\u00ED DNA. Takto mohou b\u00FDt v\u00FDznamn\u00E9 polymorfismy nalezeny, nezn\u00E1me v\u0161ak jejich roli v patogenezi onemocn\u011Bn\u00ED. Proto se pozornost obrac\u00ED ke genetick\u00E9mu vy\u0161et\u0159ov\u00E1n\u00ED endofenotyp\u016F schizofrenie. Endofenotyp je nej\u010Dast\u011Bji neurobiologick\u00E1 \u010Di neuropsychologick\u00E1 charakteristika asociovan\u00E1 s danou nemoc\u00ED, je d\u011Bdi\u010Dn\u00E1 a celo\u017Eivotn\u00ED a vyskytuje se tak\u00E9 u du\u0161evn\u011B zdrav\u00FDch p\u0159\u00EDbuzn\u00FDch pacienta. U schizofrenie jsou studov\u00E1ny zejm\u00E9na endofenotypy neurofyziologick\u00E9, neiromotorick\u00E9, neurokognitivn\u00ED, neuroanatomick\u00E9 a neurologick\u00E9. V tomto p\u0159ehledov\u00E9m \u010Dl\u00E1nku jsou nejv\u00FDznamn\u011Bj\u0161\u00ED endofenotypy schizofrenie pops\u00E1ny, zm\u00EDn\u011Bn je i jejich biologick\u00FD podklad a mo\u017En\u00E9 v\u00FDznamn\u00E9 genetick\u00E9 n\u00E1lezy. Probl\u00E9mem popisovan\u00E9ho v\u00FDzkumu je p\u0159edev\u0161\u00EDm skute\u010Dnost, \u017Ee schizofrenie je klinicky velmi heterogenn\u00ED a v\u00FDskyt endofenotyp\u016F se u jejich jednotliv\u00FDch forem m\u016F\u017Ee v\u00FDznamn\u011B li\u0161it. Budoucnost m\u00E1 multicentrick\u00FD mezin\u00E1rodn\u00ED vgenetick\u00FD v\u00FDzkum endofenotyp\u016F schizofrenie, kdy v\u0161ak ve\u0161ker\u00E9 procedury musej\u00ED b\u00FDt prov\u00E1d\u011Bny jednotn\u011B. Nalezen\u00ED a vysv\u011Btlen\u00ED genetick\u00E9ho podkladu schizofrenie m\u016F\u017Ee slou\u017Eit jejich l\u00E9\u010Db\u011B, prevenci i destigmatizaci onemocn\u011Bn\u00ED." . "Endophenotypes in genetic studies of schizophrenia"@en . . "http://www.tigis.cz/images/stories/psychiatrie/2012/03/06_hosak_psych_3-12.pdf" . . "3"^^ . . "3" . . "1"^^ .