"67" . "59982" . . "Akutn\u00ED krv\u00E1cen\u00ED do GIT a zm\u011Bny v lipidov\u00E9m spektru - pilotn\u00ED projekt"@cs . . . "Tich\u00E1, A." . . "1804-7874" . "gastrointestinal hemorrhage; lipids; cholesterol; triglycerides; sterols"@en . "RIV/00843989:_____/13:00103018" . "Akutn\u00ED krv\u00E1cen\u00ED do GIT a zm\u011Bny v lipidov\u00E9m spektru - pilotn\u00ED projekt" . "Akutn\u00ED krv\u00E1cen\u00ED do GIT a zm\u011Bny v lipidov\u00E9m spektru - pilotn\u00ED projekt" . . "Zad\u00E1k, Z." . . "1" . "Acute gastrointestinal bleeding and changes in lipid profile - pilot project"@en . "Mendlov\u00E1, Alice" . "3"^^ . . "\u00DA\u010Del studie: C\u00EDlem t\u00E9to pilotn\u00ED studie bylo popsat zm\u011Bny v lipidov\u00E9m metabolizmu u pacient\u016F s akutn\u00EDm krv\u00E1cen\u00EDm do gastrointestin\u00E1ln\u00EDho traktu (GIT) a posoudit mo\u017En\u00FD vliv hemodiluce a zm\u011Bn v procesu z\u00EDsk\u00E1v\u00E1n\u00ED cholesterolu (synt\u00E9za a absorpce).Materi\u00E1l a metody: U dvan\u00E1cti pacient\u016F s akutn\u00EDm krv\u00E1cen\u00EDm do GIT byly stanoveny hodnoty lipidov\u00E9ho metabolizmu (celkov\u00FD, LDL a HDL cholesterol, triglyceridy) v den 0, 3 a 6. Ve stejn\u00FDch term\u00EDnech byly stanoveny hladiny ukazatel\u016F cholesterolov\u00E9 synt\u00E9zy (skvalen, lathosterol) a absorpce (sitosterol, kampesterol). V\u00FDsledky byly hodnoceny srovn\u00E1n\u00EDm s kontroln\u00EDm souborem a porovn\u00E1n\u00EDm nemocn\u00FDch s cirh\u00F3zou a bez posti\u017Een\u00EDjater. Sou\u010Dasn\u011B byl hodnocen vztah mezi lipidy a hodnotami hemoglobinu, hematokritu a spot\u0159ebou transfuz\u00ED. V\u00FDsledky: Hladiny celkov\u00E9ho cholesterolu byly sn\u00ED\u017Eeny v\u00FDznamn\u011B (p < 0,001), HDL a LDL nev\u00FDznamn\u011B a triglyceridy byly v norm\u011B. Hladiny lathosterolu byly sn\u00ED\u017Eeny signifikantn\u011B (p < 0,05), skvalenu, kampesterolu a sitosterolu nesignifikantn\u011B. Porovn\u00E1n\u00ED pacient\u016F s cirh\u00F3zou a bez n\u00ED p\u0159ineslo statisticky v\u00FDznamn\u00FD rozd\u00EDl v hladin\u00E1ch cholesterolu a lathosterolu (p < 0,05). Korelace nep\u0159inesly statisticky v\u00FDznamn\u00E9 n\u00E1lezy. Z\u00E1v\u011Br: U pacient\u016F s akutn\u00EDm krv\u00E1cen\u00EDm do horn\u00EDho GITu byly prok\u00E1z\u00E1ny zm\u011Bny v metabolizmu lipid\u016F v\u010Detn\u011B alterace procesu synt\u00E9zy i absorpce. Hypocholesterolemii proto nelze vysv\u011Btlit pouze krevn\u00ED ztr\u00E1tou. Je nutn\u00E9 prov\u00E9st dal\u0161\u00ED podrobn\u011Bj\u0161\u00ED studie." . . . "\u0160vagera, Zden\u011Bk" . "Purpose of the study: The aim of this pilot study was to describe changes in lipid metabolism in patients with acute gastrointestinal (Gl) bleeding and to assess possible influence of hemodilution and changes in the cholesterol synthesis/absorption process. Material and methods: In 12 patients with gastrointestinal bleeding, the levels of lipid metabolism (total, LDL and HDL cholesterol and triglycerides) were determined on days 0, 3 and 6. On the same days, levels of the cholesterol synthesis indexes (lathosterol, squalene) and absorption (campesterol, sitosterol) were determined. The results were evaluated in comparison with the control set, and cirrhotic and non-cirrhotic patients were compared. At the same time, correlations of lipids and haemoglobin, hematocrit levels anduse of transfusions were evaluated. Results: The patients had significantly lower levels of total cholesterol (p < 0.001). Decrease of LDL and HDL cholesterol was not significant. Concentrations of triglycerides were normal. Decrease of lathosterol was significant (p < 0.05), but decrease in squalene, campesterol and sitosterol levels was insignificant. Comparing patients with cirrhosis and without cirrhosis showed statistically significant difference in levels of cholesterol and lathosterol (p < 0.05). Correlations did not show any statistically significant findings. Conclusion: In patients with acute Gl bleeding, changes is lipid metabolism including alteration of the process of synthesis and absorption were proved. Therefore, hypocholesterolemia cannot be explained by blood loss only. However, more detailed studies need to be carried out."@en . "Acute gastrointestinal bleeding and changes in lipid profile - pilot project"@en . "I, V" . "Bl\u00E1ha, V." . "Akutn\u00ED krv\u00E1cen\u00ED do GIT a zm\u011Bny v lipidov\u00E9m spektru - pilotn\u00ED projekt"@cs . "Hrabovsk\u00FD, Vladim\u00EDr" . . . "[78797FACFB6E]" . "7"^^ . "7"^^ . . "\u00DA\u010Del studie: C\u00EDlem t\u00E9to pilotn\u00ED studie bylo popsat zm\u011Bny v lipidov\u00E9m metabolizmu u pacient\u016F s akutn\u00EDm krv\u00E1cen\u00EDm do gastrointestin\u00E1ln\u00EDho traktu (GIT) a posoudit mo\u017En\u00FD vliv hemodiluce a zm\u011Bn v procesu z\u00EDsk\u00E1v\u00E1n\u00ED cholesterolu (synt\u00E9za a absorpce).Materi\u00E1l a metody: U dvan\u00E1cti pacient\u016F s akutn\u00EDm krv\u00E1cen\u00EDm do GIT byly stanoveny hodnoty lipidov\u00E9ho metabolizmu (celkov\u00FD, LDL a HDL cholesterol, triglyceridy) v den 0, 3 a 6. Ve stejn\u00FDch term\u00EDnech byly stanoveny hladiny ukazatel\u016F cholesterolov\u00E9 synt\u00E9zy (skvalen, lathosterol) a absorpce (sitosterol, kampesterol). V\u00FDsledky byly hodnoceny srovn\u00E1n\u00EDm s kontroln\u00EDm souborem a porovn\u00E1n\u00EDm nemocn\u00FDch s cirh\u00F3zou a bez posti\u017Een\u00EDjater. Sou\u010Dasn\u011B byl hodnocen vztah mezi lipidy a hodnotami hemoglobinu, hematokritu a spot\u0159ebou transfuz\u00ED. V\u00FDsledky: Hladiny celkov\u00E9ho cholesterolu byly sn\u00ED\u017Eeny v\u00FDznamn\u011B (p < 0,001), HDL a LDL nev\u00FDznamn\u011B a triglyceridy byly v norm\u011B. Hladiny lathosterolu byly sn\u00ED\u017Eeny signifikantn\u011B (p < 0,05), skvalenu, kampesterolu a sitosterolu nesignifikantn\u011B. Porovn\u00E1n\u00ED pacient\u016F s cirh\u00F3zou a bez n\u00ED p\u0159ineslo statisticky v\u00FDznamn\u00FD rozd\u00EDl v hladin\u00E1ch cholesterolu a lathosterolu (p < 0,05). Korelace nep\u0159inesly statisticky v\u00FDznamn\u00E9 n\u00E1lezy. Z\u00E1v\u011Br: U pacient\u016F s akutn\u00EDm krv\u00E1cen\u00EDm do horn\u00EDho GITu byly prok\u00E1z\u00E1ny zm\u011Bny v metabolizmu lipid\u016F v\u010Detn\u011B alterace procesu synt\u00E9zy i absorpce. Hypocholesterolemii proto nelze vysv\u011Btlit pouze krevn\u00ED ztr\u00E1tou. Je nutn\u00E9 prov\u00E9st dal\u0161\u00ED podrobn\u011Bj\u0161\u00ED studie."@cs . . "CZ - \u010Cesk\u00E1 republika" . . . . "RIV/00843989:_____/13:00103018!RIV14-MZ0-00843989" . "Gastroenterologie a hepatologie" . . . "Hy\u0161pler, R." . . .